ORIGINAL ARTICLES

  1. Simard J, Labrie F (1985) Keoxifene shows pure antiestrogenic activity in pituitary gonadotrophs. Molecular and Cellular Endocrinology, 39: 141-144.

  2. Heisler, S, Simard J, Assayag E, Mehri Y, Labrie F (1986) Atrial natriuretic factor does not affect basal, forskolin- and CRF-stimulated adenylate cyclase activity, cAMP formation or ACTH secretion, but does stimulate cGMP synthesis in anterior pituitary. Molecular and Cellular Endocrinology, 44: 125-131.

  3. Simard J, Hubert JF, Hosseinzadeh T, Labrie F (1986) Stimulation of growth hormone release and synthesis by estrogens in rat anterior pituitary cells in culture. Endocrinology 119: 2004-2011.

  4. Simard J, Hubert JF, Labrie F, Israel-Assayag E, Heisler S (1986) Atrial natriuretic factor-induced cGMP accumulation in rat anterior pituitary cells in culture is not coupled to hormonal secretion. Regulatory Peptides, 15: 269-278.

  5. Simard J, Labrie F (1986) Characteristics of the desensitization of growth hormone and cyclic AMP responses to growth hormone-releasing factor and prostaglandin E2 in rat anterior pituitary cells in culture. Molecular and Cellular Endocrinology 46: 79-89.

  6. Simard J, Labrie F, Gossard F (1986) Regulation of growth hormone mRNA and pro-opiomelanocortin mRNA levels by cyclic AMP in rat anterior pituitary cells in culture. DNA, 5: 263-270.

  7. Simard J, Luthy I, Guay J, Bélanger A, Labrie F (1986) Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Molecular and Cellular Endocrinology, 44: 261-270.

  8. Labrie F, Dupont A, Bélanger A, Emond J, Monfette G, Luthy I, Simard J, Lachance R (1987) Flutamide in combination with castration (surgical or medical) is the standard treatment in advanced prostate cancer. Journal of Drug Development, 1: 34-51.

  9. Simard J, Labrie F (1987) Adrenal C19-5-ene steroids induce full estrogenic responses in rat pituitary gonadotrophs. Journal of Steroid Biochemistry, 26: 539-546.

  10. Simard J, Lefèvre G, Labrie F (1987) Somatostatin prevents the desensitizing action of growth hormone-releasing factor on growth hormone release. Peptides, 8: 199-205.

  11. Hubert JF, Simard J, Gagné B, Barden N, Labrie F (1988) Effect of luteinizing hormone-releasing hormone (LHRH) and [D-Trp6, des-Gly-NH210] LHRH ethylamide on α-subunit and LHβ messenger ribonucleic acid levels in rat anterior pituitary cells in culture. Molecular Endocrinology, 2: 521-527.

  12. Pelletier G, Labrie C, Simard J, Duval M, Martinoli MG, Zhao HF, Labrie F (1988) Effects of sex steroids on regulation of the levels of C1 peptide of rat prostatic steroid-binding protein mRNA evaluated by insitu hybridization. Journal of Molecular Endocrinology, 1: 213-223.

  13. Simard J, Labrie C, Hubert JF, Labrie F (1988) Modulation by sex steroids and [D-Trp6, des-Gly-NH210] LHRH ethylamide of α-subunit and LHβ mRNA levels in the rat anterior pituitary gland. Molecular Endocrinology, 2: 775-784.

  14. Simard J, Vincent A, Duchesne R, Labrie F (1988) Full estrogenic activity of C19-∆5 adrenal steroids in rat pituitary lactotrophs and somatotrophs. Molecular and Cellular Endocrinology, 55: 233-242.

  15. Dumont M, Dauvois S, Simard J, Garcia T, Schachter B, Labrie F (1989) Antagonism between estrogens and androgens on GCDFP-15 gene expression in ZR-75-1 cells and correlation between GCDFP-15 and estrogen as well as progesterone receptor expression in human breast cancer. Journal of Steroid Biochemistry, 34: 397-402.

  16. Labrie F, Luu-The V, Labrie C, Bérubé D, Couët J, Zhao HF, Gagné, R, Simard J (1989) Characterization of two mRNA species encoding human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17. Journal of Steroid Biochemistry, 34: 189-197.

  17. Labrie C, Simard J, Zhao HF, Bélanger A, Pelletier G, Labrie F (1989) Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate. Endocrinology, 124: 2745-2754.

  18. Luu-The V, Labrie C, Zhao HF, Couët J, Lachance Y, Simard J, Leblanc, G, Côté J, Bérubé D, Gagné R, Labrie F (1989) Characterization of cDNAs for human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5' termini in human placenta. Molecular Endocrinology, 3: 1301-1309.

  19. Poulin R, Simard J, Labrie C, Petitclerc L, Dumont M, Lagacé L, Labrie F (1989) Down-regulation of estrogen receptors by androgens in the ZR-75-1 human breast cancer cell line. Endocrinology, 125: 392-399.

  20. Simard J, Hatton AC, Labrie C, Dauvois S, Zhao HF, Haagensen DE, Labrie F (1989) Inhibitory effect of estrogens on GCDFP-15 mRNA levels and secretion in ZR-75-1 human breast cancer cells. Molecular Endocrinology, 3: 694-702.

  21. Tong Y, Simard J, Labrie C, Zhao HF, Labrie F, Pelletier G. (1989) Inhibitory effect of androgen on estrogen-induced prolactin messenger ribonucleic acid accumulation in the male rat anterior pituitary gland. Endocrinology, 125: 1821-1828.

  22. Tong Y, Zhao HF, Simard J, Labrie F, Pelletier G (1989) Electron microscopic autoradiographic localization of prolactin mRNA in rat pituitary. Journal of Histochemistry and Cytochemistry, 37: 567-571.

  23. Toranzo D, Dupont E, Simard J, Labrie C, Couët J, Labrie F, Pelletier G (1989) Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats. Molecular Endocrinology, 3: 1748-1756.

  24. Zhao HF, Simard J, Labrie C, Breton N, Rhéaume R, Luu-The V, Labrie F (1989) Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3β-hydroxy-5-ene-steroid dehydrogenase/∆5-∆4 isomerase. FEBS Letters, 259: 153-157.

  25. Baker ME, Luu-The V, Simard J, Labrie F (1990) A common ancestor for mammalian 3b-hydroxysteroid dehydrogenase and plant dihydroflavonol reductase. Biochemical Journal, 269: 558-559.

  26. Dauvois S, Simard J, Dumont M, Haagensen DE, Labrie F (1990) Opposite effects of estrogen and the progestin R5020 on cell proliferation and GCDFP-15 expression in ZR-75-1 human breast cancer cells. Molecular and Cellular Endocrinology, 73: 171-178.

  27. Dupont E, Zhao HF, Rhéaume E, Simard J, Luu-The V, Labrie F, Pelletier G (1990) Localization of 3β -hydroxysteroid dehydrogenase/∆5-∆4 isomerase in the rat gonads and adrenal glands by immunocytochemistry and in situ hybridization. Endocrinology, 127: 1394-1403.

  28. Labrie F, Bélanger A, Dupont A, Pelletier G, Luu-The V, Simard J, Cusan L. Labrie C, Lachance Y, Poulin R, Dupont E, Zhao HF, Martel C (1990) Synthèse périphérique des androgènes chez l'homme. Génétique moléculaire du système et sa prise en compte dans le traitement du cancer de la prostate. Médecine-Sciences, 6: 261-267.

  29. Labrie C, Simard J, Zhao HF, Pelletier G, Labrie F (1990) Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate. Molecular and Cellular Endocrinology, 68: 169-179.

  30. Lachance Y, Luu-The V, Labrie C. Simard J, Dumont M, de Launoit Y, Guérin S, Leblanc G, Labrie F (1990) Characterization of human 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase gene and its expression in mammalian cells. Journal of Biological Chemistry, 265: 20469-20475.

  31. Luu-The V, Labrie C, Simard J, Lachance Y, Zhao HF, Couët J, Leblanc G, Labrie F (1990) Structure of two in tandem human 17β-hydroxysteroid dehydrogenase genes. Molecular Endocrinology, 4: 268-275.

  32. Martel C, Labrie C, Dupont E, Couët J, Trudel C, Rhéaume E, Simard J, Luu-The V, Pelletier G, Labrie F (1990) Regulation of 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase expression and activity in the hypophysectomized rat ovary: interactions between the stimulatory effect of human chorionic gonadotropin and the luteolytic effect of prolactin. Endocrinology, 127: 2726-2737.

  33. Rhéaume E, Tonon MC, Smih F, Simard J, Désy L, Vaudry H, Pelletier G (1990) Localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in the rat testis. Endocrinology, 127: 1986-1994.

  34. Simard J, Dauvois S, Haagensen DE, Lévesque C, Mérand Y, Labrie F (1990) Regulation of progesterone-binding breast cyst protein GCDFP-24 secretion by estrogens and androgens in human breast cancer cells: a new marker of steroid action in breast cancer. Endocrinology, 126: 3223-3231.

  35. Tong Y, Couët J, Simard J, Pelletier G (1990) Glucocorticoid regulation of proopiomelanocortin mRNA levels in rat arcuate nucleus. Molecular and Cellular Neurosciences, 1: 78-83.

  36. Zhao HF, Rhéaume E, Trudel C, Couët J, Labrie F, Simard J (1990) Structure and sexual dimorphic expression of a liver-specific rat 3β-hydroxysteroid dehydrogenase/isomerase. Endocrinology, 127: 3237-3239.

  37. Zorilla R, Simard J, Rhéaume E, Labrie F, Pelletier G (1990) Multihormonal control of pre-pro-somatostatin mRNA levels in the periventricular nucleus of the male and female rat hypothalamus. Neuroendocrinology, 52: 527-536.

  38. de Launoit Y, Dauvois S, Dufour M, Simard J, Labrie F (1991) Inhibition of cell cycle kinetics and proliferation by the androgen 5α-dihydrotestosterone and antiestrogen N, n-butyl-N-methyl-11-[16'α-chloro-3',17β-dihydroxy-estra-1',3',5'-(10')triene-7'α-yl] undeca-namide in human breast cancer ZR-75-1 cells. Cancer Research, 51: 2797-2802.

  39. de Launoit Y, Veilleux R, Dufour M, Simard J, Labrie F (1991) Characteristics of the biphasic action of androgens and of the potent antiproliferative effects of the new pure antiestrogen EM-139 on cell cycle kinetic parameters in LNCaP human prostatic cancer cells. Cancer Research, 51: 5165-5170.

  40. Dupont E, Rhéaume E, Simard J, Luu-The V, Labrie, F, Pelletier G (1991) Ontogenesis of 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase in the rat adrenal as revealed by immunocytochemistry and in situ hybridization. Endocrinology, 129: 2687-2692.

  41. Labrie F, Simard J, Luu-The V, Trudel C, Martel C, Labrie C, Zhao HF, Rhéaume E, Couët J, Breton N (1991) Expression of 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase (3β-HSD) and 17β–hydroxysteroid dehydrogenase (17β-HSD) in adipose tissue. International Journal of Obesity, 15 Suppl. 2: 91-99.

  42. Pelletier G, Simard J (1991) Dopaminergic regulation of pre-proNPY mRNA levels in the rat arcuate nucleus. Neuroscience Letters, 127: 96-98.

  43. Pelletier G, Tong Y, Rhéaume E, Simard J, Tonon MC, Vaudry H (1991) Localization of endogenous benzodiazepine ligand octadecaneuropeptide (ODN) and peripheral benzodiazepine receptors in the rat prostate. Molecular Andrology, 3: 95-108.

  44. Rhéaume E, Lachance Y, Zhao HF, Breton N, Dumont M, de Launoit Y, Trudel C, Luu-The V, Simard J, Labrie F (1991) Structure and expression of a new cDNA encoding the almost exclusive 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase in human adrenals and gonads. Molecular Endocrinology, 5: 1147-1157.

  45. Rhéaume E, Leblanc JF, Lachance Y, Labrie F, Simard J (1991) Detection of a frequent Bgl II polymorphism by PCR and Taq I RFLP for 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase at the human HSDB3 locus (1p11-p13). Human Genetics, 87: 753-754.

  46. Rhéaume E, Sirois I, Labrie F, Simard J (1991) Codon 367 polymorphism of the human type I 3β-hydroxysteroid dehydrogenase/isomerase gene (HS5 DB3). Nucleic Acids Research, 19: 6060.

  47. Simard J, de Launoit Y, Labrie F (1991) Characterization of the structure-activity relationships of rat types I and II 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase by site-directed mutagenesis and expression in HeLa cells. Journal of Biological Chemistry, 266: 14842-14845.

  48. Simard J, Melner MH, Breton N, Low KG, Zhao HF, Periman LM, Labrie F (1991) Characterization of macaque 3β-hydroxy-5-ene steroid dehydrogenase/∆5-∆4 isomerase: structure and expression in steroidogenic and peripheral tissues in primate. Molecular and Cellular Endocrinology, 75: 101-110.

  49. Simard J, Veilleux R, de Launoit Y, Haagensen DE, Labrie F (1991) Stimulation of apoliprotein D secretion by steroids coincides with inhibition of cell proliferation in human LNCaP prostate cancer cells. Cancer Research, 51: 4336-4341.

  50. Tong Y, Rhéaume E, Simard J, Pelletier G (1991) Localization of peripheral benzodiazepine binding sites and diazepam-binding inhibitor (DBI) mRNA in mammary glands and dimethylbenz(α)anthrene(DMBA)-induced mammary tumors in the rat. Regulatory Peptides, 33: 263-273.

  51. Zhao HF, Labrie C, Simard J, de Launoit Y, Trudel C, Martel C, Rhéaume E, Dupont E, Luu-The V, Pelletier G, Labrie F (1991) Characterization of rat 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase cDNAs and differential tissue-specific expression of corresponding mRNAs in steroidogenic and peripheral tissues. Journal of Biological Chemistry, 266: 583-593.

  52. Zorilla R, Simard J, Labrie F, Pelletier G (1991) Variations of pre-somatostatin mRNA levels in the hypothalamic periventricular nucleus during the rat estrous cycle. Molecular and Cellular Neurosciences, 2: 294-298.

  53. Couët J, Simard J, Martel C, Trudel C, Labrie Y, Labrie F (1992) Regulation of 3-ketosteroid reductase messenger ribonucleic acid levels and 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase activity in rat liver by sex steroids and pituitary hormones. Endocrinology, 131: 3034-3044.

  54. de Launoit Y, Simard J, Durocher F, Labrie F (1992) Androgenic 17β-hydroxysteroid dehydrogenase activity of expressed rat type I 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase. Endocrinology, 130: 553-555.

  55. de Launoit Y, Zhao HF, Bélanger A, Labrie F, Simard J (1992) Expression of liver-specific member of the 3β-hydroxysteroid dehydrogenase family, an isoform possessing an almost exclusive 3-ketosteroid reductase activity. Journal of Biological Chemistry, 267: 4513-4517.

  56. Foss KB, Simard J, Bérubé D, Beebe SJ, Sandberg M, Grzeschik KH, Gagné R, Hansson V, Jahnsen T (1992) Localization of the catalytic subunit C of cAMP-dependent protein kinase on human chromosome 9 q13. Cytogenetics and Cell Genetics, 60: 22-25.

  57. Kaynard AH, Periman LM, Simard J, Melner MH (1992) Ovarian 3β-hydroxysteroid dehydrogenase and sulfated glycoprotein-2 gene expression are differentially regulated by the induction of ovulation, pseudopregnancy, and luteolysis in the immature rat. Endocrinology, 130: 2192-2200.

  58. Labrie F, Simard J, de Launoit Y, Poulin, R, Thériault C, Dumont M, Dauvois S, Martel C, Li, SM (1992) Androgens and breast cancer. Cancer Detection and Prevention, 16: 31-38.

  59. Labrie F, Simard J, Luu-The V, Bélanger A, Pelletier G (1992) Structure, function and tissue-specific gene expression of multiple 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase isoenzymes in classical and peripheral intracrine steroidogenic tissues. Journal of Steroid Biochemistry and Molecular Biology, 43: 805-826.

  60. Labrie F, Simard J, Luu-The V, Pelletier G, Bélanger A, Lachance Y, Zhao HF, Labrie C, Breton N, de Launoit Y, Dumont M, Dupont E, Rhéaume E, Martel C, Couët J, Trudel C (1992) Structure and tissue-specific expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues. Journal of Steroid Biochemistry and Molecular Biology, 41: 421-435.

  61. Labrie F, Sugimoto Y, Luu-The V, Simard J, Lachance Y, Bachvarov D, Leblanc G, Durocher F, Paquet N (1992) Structure of human type II 5α-reductase gene. Endocrinology, 131: 1571-1573.

  62. Martel C, Rhéaume E, Takahashi M, Trudel C, Couët J, Luu-The V, Simard J, Labrie F (1992) Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues. Journal of Steroid Biochemistry and Molecular Biology, 41: 597-603.

  63. Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T. (1992) Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10. Cytogenetics and Cell Genetics, 59: 270-273.

  64. Pelletier G, Dupont E, Simard J, Luu-The V, Bélanger A, Labrie F (1992) Ontogeny and subcellular localization of 3β-hydroxysteroid dehydrogenase (3β-HSD) in the human and rat adrenal, ovary and testis. Journal of Steroid Biochemistry and Molecular Biology, 43: 451-467.

  65. Pelletier G, Rhéaume E, Simard J (1992) Variations of pre-proNPY mRNA in the arcuate nucleus during the rat estrous cycle. NeuroReport, 3: 253-255.

  66. Rhéaume E, Simard J, Morel Y, Mébarki F, Zachmann M, Forest MG, New MI, Labrie F (1992) Congenital adrenal hyperplasia due to point mutations in the type II 3β-hydroxysteroid dehydrogenase gene. Nature Genetics, 1: 239-245.

  67. Simard J, Bérubé D, Sandberg M, Grzeschik KH, Gagné R, Hansson V, Jahnsen T (1992) Assignment of the gene encoding the catalytic subunit Cβ or cAMP-dependent protein kinase to the p36 band on chromosome 1. Human Genetics, 88: 653-657.

  68. Simard J, de Launoit Y, Haagensen DE, Labrie F (1992) Additive stimulatory action of glucocorticoids and androgens on basal and estrogen-repressed apolipoprotein D messenger RNA levels and secretion in human breast cancer cells. Endocrinology, 130: 1115-1121.

  69. Simard J, Luu-The V, Labrie F (1992) Structure and expression of the genes encoding the enzymes for ovarian and peripheral steroidogenesis. J. Gynecol. Obstet. Biol. Reprod., (Paris) 21: 292-295.

  70. Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (1992) Mapping of the regulatory subunits RIβ- and RIIβ of cAMP-dependent protein kinase genes on human chromosome 7. Genomics, 14: 63-69.

  71. Couture P, Thériault C, Simard J, Labrie F (1993) Androgen receptor-mediated stimulation of 17β-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxy-progesterone acetate in ZR-75-1 human breast cancer cells. Endocrinology, 132: 179-185.

  72. Labrie F, Bélanger A, Dupont A, Luu-The V, Simard J, Labrie C (1993) Science behind total androgen blockade: from gene to combination therapy. Clinical and Investigative Medicine, 16: 475-492.

  73. Labrie F, Bélanger A, Simard J, Labrie C, Dupont A (1993) Combination therapy for prostate cancer. Endocrine and biologic basis of its choice as new standard first-line therapy. Cancer, 71: 1059-1067.

  74. Labrie F, Dupont A, Simard J, Luu-The V, Bélanger A (1993) Intracrinology: the basis for the rational design of endocrine therapy at all stages of prostate cancer. European Urology, 24: 94-105.

  75. Normand T, Narod SA, Labrie F, Simard J (1993) Detection of polymorphisms in the estradiol 17β-hydroxysteroid dehydrogenase II gene at the EDH17B2 Locus on 17q11-q21. Human Molecular Genetics, 2: 479-483.

  76. Simard J, Couët J, Durocher F, Labrie Y, Sanchez R, Breton N, Turgeon C, Labrie F (1993) Structure and tissue-specific expression of a novel member of the rat 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase (3β-HSD) family. The exclusive 3β-HSD gene expressed in the skin. Journal of Biological Chemistry, 268: 19659-19668.

  77. Simard J, Feunteun J, Lenoir G, Tonin P, Normand T, Luu-The V, Vivier A, Lasko D, Morgan K, Rouleau GA, Lynch H, Labrie F, Narod SA (1993) Genetic mapping of the breast-ovarian cancer syndrome to a small interval on chromosome 17q12-21: exclusion of candidate genes EDH17B2 and RARA. Human Molecular Genetics, 2: 1193-1199.

  78. Simard J, Rhéaume E, Sanchez R, Laflamme N, de Launoit Y, Luu-The V, van Seters AP, Gordon RD, Bettendorf M, Heinrich U, Moshang T New MI, Labrie F (1993) Molecular basis of congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency. Molecular Endocrinology, 7: 716-728.

  79. Blais Y, Sugimoto K, Carrière MC, Haagensen DE, Labrie F, Simard J (1994) Potent stimulatory effect of interleukin-1α on apolipoprotein D and gross cystic disease fluid protein-15 expression in human breast cancer cells. International Journal of Cancer, 59: 400-407.

  80. Couët J, Martel C, Labrie Y, Luo S, Simard J, Labrie F (1994) Opposite effects of prolactin and corticosterone on the expression and activity of 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase in rat skin. Journal of Investigative Dermatology, 103: 60-64.

  81. Dupont E, Simard J, Luu-The V, Labrie F, Pelletier G (1994) Localization of 3β-hydroxysteroid dehydrogenase in rat brain as studied by in situ hybridization. Molecular and Cellular Neurosciences, 5 : 119-123.

  82. Eskild W, Robidoux S, Simard J, Hansson V, Guérin SL (1994) Binding of a member of the NF1 family of transcription factors to two distinct cis-acting elements in the promoter and 5'-flanking region of the human cellular retinol binding protein 1 gene. Molecular Endocrinology, 8: 732-745.

  83. Labrie Y, Couët J, Simard J, Labrie F (1994) Multihormonal regulation of dehydroepiandrosterone sulfotransferase messenger ribonucleic acid levels in adult rat liver. Endocrinology, 134: 1693-1699.

  84. Labrie F, Simard J, Luu-The V, Pelletier G, Belghmi K, Bélanger A (1994) Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in formation of sex steroids in classical and peripheral intracrine tissues. Baillieres Clin Endocrinol Metab, 8: 451-474.

  85. Martel C, Gagné D, Couët J, Labrie Y, Simard J, Labrie F (1994) Rapid modulation of ovarian 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase gene expression by prolactin and human chorionic gonadotropin in the hypophysectomized rat. Molecular and Cellular Endocrinology, 99: 63-71.

  86. Martel C, Melner MH, Gagné D, Simard J, Labrie F (1994) Widespread tissue distribution of steroid sulfatase, 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase (3β-HSD), 17β-HSD 5α-reductase and aromatase activities in the rhesus monkey. Molecular and Cellular Endocrinology, 104: 103-111.

  87. Poirier D, Auger S, Mérand Y, Simard J, Labrie F (1994) Synthesis and antiestrogenic activity of diaryl thioether derivatives. Journal of Medicinal Chemistry, 37: 1115-1125.

  88. Rhéaume E, Sanchez R, Simard J, Chang YT, Wang J, Pang S, Labrie F (1994) Molecular basis of congenital adrenal hyperplasia in two siblings with classical nonsalt-losing 3β-hydroxysteroid dehydrogenase deficiency. Journal of Clinical Endocrinology and Metabolism, 79: 1012-1018.

  89. Sanchez R, de Launoit Y, Durocher F, Bélanger A, Labrie F, Simard J (1994) Formation and degradation of dihydrotestosterone by recombinant members of the rat 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase family. Molecular and Cellular Endocrinology, 103: 29-38.

  90. Sanchez R, Mébarki F, Rhéaume E, Laflamme N, Forest MG, Bey-Omard F, David M, Morel Y, Labrie F, Simard J (1994) Functional characterization of the novel L108W and P186L mutations detected in the type II 3β-hydroxysteroid dehydrogenase gene of a male pseudohermaphrodite with congenital adrenal hyperplasia. Human Molecular Genetics, 3: 1639-1645.

  91. Sanchez R, Rhéaume E, Laflamme N, Rosenfield RL, Labrie F, Simard J (1994) Detection and functional characterization of the novel missense mutation Y254D in type II 3β-hydroxysteroid dehydrogenase (3β-HSD) gene of a female patient with nonsalt-losing 3β-HSD deficiency. Journal of Clinical Endocrinology and Metabolism, 78: 561-567.

  92. Simard J, Moorjani S, Vohl MC, Couture P, Torres AL, Gagné C, Després JP, Labrie F, Lupien PJ (1994) Detection of the novel mutation (stop 468) in exon 10 of the low-density lipoprotein (LDL) receptor gene causing familial hypercholesterolemia among French Canadians. Human Molecular Genetics, 3: 1689-1691.

  93. Simard J, Rhéaume E, Leblanc JF, Wallis SC, Joplin GF, Gilbey S, Allanson J, Mettler G, Bettendorf M, Heinrich U, Labrie F (1994) Congenital adrenal hyperplasia caused by a novel homozygous frameshift mutation 273ΔAA in type II 3β-hydroxysteroid dehydrogenase gene (HSD3B2) in three male patients of Afghan/Pakistani origin. Human Molecular Genetics, 3: 327-330.

  94. Simard J, Tonin P, Durocher F, Morgan K, Rommens J, Gingras S, Samson C, Leblanc JF, Bélanger C, Dion F, Liu Q, Skolnick M, Shattuck-Bidens D, Goldgar D, Labrie F, Narod SA (1994) Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families. Nature Genetics, 8: 392-398.

  95. Sugimoto K, Simard J, Haagensen DE, Labrie F (1994) Inverse relationships between cell proliferation and basal or androgen-stimulated apolipoprotein D secretion in LNCaP human prostate cancer cells. Journal of Steroid Biochemistry and Molecular Biology, 51: 167-174.

  96. Tonin P, Serova O, Simard J, Lenoir G, Feunteun J, Morgan K, Lynch H, Narod SA (1994) The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. Human Molecular Genetics, 3: 1679-1682.

  97. Verreault H, Dufort I, Simard J, Labrie F, Luu-The V (1994) Dinucleotide repeat polymorphisms in the HSD3B2 gene. Human Molecular Genetics, 3: 384.

  98. Zerah M, Rhéaume E, Mani P, Schram P, Simard J, Labrie F, New MI (1994) No evidence of mutations in the genes for Type I and Type II 3b-hydroxysteroid dehydrogenase (3bHSD) in nonclassical 3bHSD deficiency. Journal of Clinical Endocrinology and Metabolism, 79: 1811-1817.

  99. Blais Y, Sugimoto K, Carrière MC, Haagensen DE, Labrie F, Simard J (1995) Interleukin-6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin-1α on apolipoprotein D and GCDFP-15 expression in human breast cancer cells. International Journal of Cancer, 62: 732-737.

  100. Chen C, Puy LA, Simard J, Li X, Singh SM, Labrie F (1995) Local and systemic reduction by topical finasteride or flutamide on hamster flank organ size and enzyme activity. Journal of Investigative Dermatology, 105: 678-682.

  101. Dalla Valle L, Couët J, Labrie Y, Simard J, Belvedere P, Simontacchi C, Labrie, F, Colombo L (1995) Occurrence of cytochrome P450c17 mRNA and dehydro-epiandrosterone biosynthesis in the rat gastrointestinal tract. Molecular and Cellular Endocrinology, 111: 83-92.

  102. Durocher F, Morissette J, Dufort I, Simard J, Luu-The V (1995) Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region. Genomics, 29: 781-783.

  103. Durocher F, Morissette J, Labrie Y, Labrie F, Simard J (1995) Mapping of the HSD17B2 gene encoding type II 17β-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q 24.1-q24.2. Genomics, 25: 724-726.

  104. Labrie F, Bélanger A, Simard J, Luu-The V, Labrie C (1995) Intracrinology. Autonomy and freedom of peripheral tissues. Ann. Endocrinol., 56: 23-29.

  105. Labrie Y, Durocher F, Lachance Y, Turgeon C, Simard J, Labrie C, Labrie F (1995) The human type II 17β-hydroxysteroid dehydrogenase gene encodes two alternatively spliced messenger RNA species. DNA and Cell Biology, 14: 849-861.

  106. Mébarki F, Sanchez R, Rhéaume E, Laflamme N, Simard J, Forest MG, Bey-Omard F, David M, Labrie F, Morel Y (1995) Nonsalt-losing male pseudohermaphroditism due to the novel homozygous N100S mutation in the type II 3β-hydroxysteroid dehydrogenase gene. Journal of Clinical Endocrinology and Metabolism, 80: 2127-2134.

  107. Morissette J, Rhéaume E, Leblanc JF, Luu-The V, Labrie F, Simard J (1995) Genetic linkage mapping of HSD3B1 and HSD3B2 encoding human types I and II 3β-hydroxysteroid dehydrogenase/∆5-∆4-isomerase close to D1S514 and the centromeric D1Z5 locus. Cytogenetics and Cell Genetics, 69: 59-62.

  108. Rhéaume E, Sanchez R, Mébarki F, Gagnon E, Carel JC, Chaussain JL. Morel Y, Labrie F, Simard J (1995) Identification and characterization of the G15D mutation found in a male patient with 3β-hydroxysteroid dehydrogenase (3β-HSD) deficiency: alteration of the putative NAD-binding domaine of type II 3β-HSD. Biochemistry, 34: 2893-2900.

  109. Rommens JM, Durocher F, McArthur J, Tonin P, Leblanc JF, Allen T, Samson C, Ferri L, Narod SA, Morgan K, Simard J (1995) Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. Genomics, 28: 530-542.

  110. Shattuck-Eidens D, McClure M, Simard J, Labrie F, Narod SA, Weber B, Collins F, Friedman L, Ostermeyer E, Szabo C, King MC, Jhanwar S, Offit K, Norton L, Gilewski T, Lubin M, Osborne M, Black D, Boyd M, Steel M, Ingles S, Haile R, Borg A, Lindblom A, Gayther S, Ponder B, Warren B, Stratton M, Liu Q, Kamb A, Fujimura F, Skolnick M, Goldgar DE (1995) A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications of presymptomatic testing and screening. Journal of the American Medical Association, 273: 535-541.

  111. Simard J, Rhéaume E, Mébarki F, Sanchez R, New MI, Morel Y, Labrie F (1995) Molecular basis of human 3β-hydroxysteroid dehydrogenase deficiency. Journal of Steroid Biochemistry and Molecular Biology, 53: 127-138.

  112. Simard J, Sanchez R, Durocher F, Rhéaume E, Turgeon C, Labrie Y, Luu-The V, Mebarki F, Morel Y, de Launoit Y, Labrie F (1995) Structure-function relationship and molecular genetics of the 3β-hydroxysteroid dehydrogenase gene family. Journal of Steroid Biochemistry and Molecular Biology, 55: 489-505.

  113. Tonin P, Moslehi R, Normand T, Vivier A, Miller S, Ginsburg O, Cutler C, Margolese R, McGillivray B, Labrie F, Simard J, Narod SA (1995) Linkage analysis of 26 canadian breast and breast-ovarian cancer families. Human Genetics, 5: 545-550.

  114. Tonin P, Serova O, Lenoir G, Lynch H, Durocher F, Simard J, Morgan K, Narod SA (1995) BRCA1 mutations in Ashkenazi Jewish women. American Journal of Human Genetics, 57: 189.

  115. Vohl MC, Couture P, Moorjani S, Torres AL, Gagné C, Després JP, Lupien PJ, Labrie F, Simard J (1995) Rapid restriction fragment analysis for screening of four point mutations of the low-density lipoprotein receptor gene in French Canadians. Human Mutation, 6: 243-246.

  116. Blais Y, Gingras S, Haagensen DE, Labrie F, Simard J (1996) Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells. Molecular and Cellular Endocrinology, 121: 11-18.

  117. Couch FJ, Farid LM, DeShano ML, Tavtigian SV, Calzone K, Campeau L, Peng Y, Bogden B, Chen Q, Neuhausen S, Shattuck-Eidens D, Godwin AK, Daly M, Radford DM, Sedlacek S, Rommens J, Simard J, Garber J, Merajver S, Weber BL (1996) BRCA2 germline mutations in male breast cancer cases and breast cancer families. Nature Genetics, 13: 123-125.

  118. Couch FJ, Rommens JM, Neuhausen SL, Bélanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Stringfellow M, Stroup C, Swedlund B, Swensen J, Teng D, Thakur S, Tran T, Tranchant M, Welver-Feldhaus J, Wong AKC, Labrie F, Skolnick MH, Goldgar DE, Kamb A, Weber BL, Tavtigian SV, Simard J (1996) Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. Genomics, 36: 86-99.

  119. Couch FJ, Weber BL, (BIC) and the BCIC (1996) Mutations and polymorphisms in the familial early onset breast cancer (BRCA1) gene. Human Mutations, 8-18.

  120. Durocher F, Shattuck-Eidens D, McClure M, Labrie F, Skolnick MH, Goldgar DE, Simard J (1996) Comparison of BRCA1 polymorphisms, rare sequence variants and/or missense mutations in unaffected and breast/ovarian cancer populations. Human Molecular Genetics, 5: 835-842.

  121. Durocher F, Tonin P, Shattuck-Eidens D, Skolnick M, Narod SA, Simard J (1996) Mutation analysis of the BRCA1 gene in 23 families with cases of cancer of the breast, ovary and multiple other sites. Journal of Medical Genetics, 33: 814-819.

  122. Labrie F, Bélanger A, Cusan L, Labrie C, Simard J, Luu-The V, Diamond P, Gomez JL, Candas B (1996) History of LHRH agonist and combination therapy in prostate cancer. Endocrine-Related Cancer, 3: 243-278.

  123. Laflamme N, Leblanc JF, Mailloux J, Faure N, Labrie F, Simard J (1996) Mutation R96W in cytochrome P450c17 gene causes combined 17α-hydroxylase/17-20 lyase deficiency in two French Canadian patients. Journal of Clinical Endocrinology and Metabolism, 81: 264-268.

  124. Luo S, Martel C, Leblanc G, Candas B, Singh SM, Labrie C, Simard J, Bélanger A, Labrie F (1996) Relative potencies of flutamide and casodex: preclinical studies. Endocrine-Related Cancer, 3: 229-241.

  125. Morissette J, Durocher F, Leblanc JF, Normand T, Labrie F, Simard J (1996) Genetic linkage mapping of the human steroid 5α-reductase type 2 gene (SRD5A2) close to D2S352 on chromosome region 2p23 p22. Cytogenetics and Cell Genetics, 73: 304-307.

  126. Puy LA, Turgeon C, Gagné D, Labrie Y, Chen C, Pelletier G, Simard J, Labrie F (1996) Localization and regulation of expression of the FAR-17A gene in the hamster flank organs. Journal of Investigative Dermatology, 107: 44-50.

  127. Simard J, Durocher F, Mébarki F, Turgeon C, Sanchez R, Labrie Y, Couët J, Trudel C, Rhéaume E, Morel Y, Luu-The V, Labrie F (1996) Molecular biology and genetics of the 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase gene family. Journal of Endocrinology, 150: S189-S207.

  128. Tavtigian SV, Simard J, Rommens J, Couch F, Shattuck-Eidens D, Neuhausen S, Merajver S, Thorlacius S, Offit K, Stoppa-Lyonnet D, Bélanger C, Bell R, Berry S, Bogden R, Chen Q, Davis T, Dumont M, Frye C, Hattier T, Jammulapati S, Janecki T, Jiang P, Kehrer R, Leblanc JF, Mitchell JT, Peng Y, Samson C, Schroeder M, Snyder S, Stringfellow M, Stroup C, Swedlund B, Swensen J, Teng D, Thomas A, Tran T, Tranchant M, Weaver-Feldhaus J, Wong AKC, Shizuya H, Eyfjord JE, Cannon-Albright L, Labrie F, Skolnick M, Weber B, Kamb A, Goldgar DE (1996) The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genetics, 12: 333-337.

  129. Durocher F, Simard J, Ouellette J, Richard V, Labrie F, Pelletier G (1997) Localization of BRCA1 gene expresion in adult cynomolgus monkey tissues. Journal of Histochemistry and Cytochemistry, 45: 1173-1188.

  130. Foss KB, Solberg R, Simard J, Myklebust F, Hansson V, Jahnsen T, Taskén K (1997) Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII a of cAMP-dependent protein kinase. BBA - Biochimica & Biophysica Acta, 1350: 98-108.

  131. Gauthier S, Caron B, Cloutier J, Dory YL, Favre A, Larouche D, Mailhot J, Ouellet C, Schwerdtfeger A, Leblanc G, Martel C, Simard J, Mérand Y, Bélanger A, Labrie C, Labrie F (1997) (S)-(+)-[4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl) ethoxy]phenyl]-2H-1-benzopyran-3-yl]phenyl]-2,2-dimethylpropanoate (EM-800): a highly potent, specific and orally active non-steroidal antiestrogen. Journal of Medicinal Chemistry, 40: 2117-2122.

  132. Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R, Bélanger A (1997) The key role of 17β-HSDs in sex steroid biology. Steroids, 62: 148-158.

  133. Labrie F, Simard J, Candas B (1997) Reply to the authors (PF Schellhammer). Urology, 49: 586-589.

  134. Labrie F, Simard J, Singh SM, Candas B (1997) Estimated potency of Casodex: a problematic design (letter, comment). Urology, 50: 309-313.

  135. Morel Y, Mébarki F, Rhéaume E, Sanchez R, Forest MG, Simard J (1997) Structure-function relationships of 3β-hydroxysteroid dehydrogenase: contribution made by the molecular genetics of 3β-hydroxysteroid dehydrogenase defiency. Steroids, 62: 176-184.

  136. Poulin MJ, Simard J, Catford JG, Labrie F, Piché Y (1997) Response of symbiotic endomycorrhizal fungi to estrogens and antiestrogens. Molecular Plant-Microbe Interactions, 10: 481-487.

  137. Simard J, Labrie C, Bélanger A, Gauthier S, Singh SM, Mérand Y, Labrie F (1997) Characterization of the effects of the novel non-steroidal antiestrogen EM-800 on basal and estrogen-induced proliferation of T-47D, ZR-75-1 and MCF-7 human breasts cancer cells in vitro. International Journal of Cancer, 73: 104-112.

  138. Simard J, Sanchez R, Poirier D, Gauthier S, Singh SM, Mérand Y, Bélanger A, Labrie C, Labrie F (1997) Blockade of the stimulatory effect of estrogens, OH-Tamoxifen, OH-Toremifene, Droloxifene, and Raloxifene on alkaline phosphatase activity by the antiestrogen EM-800 in human endometrial adenocarcinoma Ishikawa cells. Cancer Research, 57: 3494-3497.

  139. Simard J, Singh SM, Labrie F (1997) Comparison of in vitro effects of the pure antiandrogens OH-Flutamide, Casodex, and Nilutamide on androgen-sensitive parameters. Urology, 49: 580-589.

  140. Couture P, Brun LD, Szots F, Lelièvre M, Gaudet D, Després JP, Simard J, Lupien PJ, Gagné C (1998) Association of specific LDL receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 1007-1012.

  141. Couture P, Demers C, Morissette J, Delage R, Jomphe M, Couture L, Simard J (1998) Type I protein C defiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels. Journal of Trombosis Haemostasis, 80: 551-556.

  142. Couture P, Vohl MC, Gagné C, Gaudet D, Torres AL, Lupien PJ, Després JP, Labrie F, Simard J, Moorjani S (1998) Identification of three mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia among French Canadians. Human Mutation, Supplement: S226-S231.

  143. Durocher F, Simard J, Ouellette J, Richard V, Pelletier G (1998) BRCA1 gene expression in reproductive and endocrine tissues in adult cynomolgus monkey. Annals of the New York Academy of Sciences, Volume 839.

  144. Durocher F, Morissette J, Simard J (1998) Genetic linkage mapping of the CYP11A1 gene encoding the cholesterol side-chain cleavage P450scc close to the CYP1A1 gene and D15S204 in the chromosome 15q22.33-q23 region. Pharmacogenetics, 8: 49-53.

  145. Eeles RA, Durocher F, Edwards S, Teare D, Badzioch M, Hamoudi R, Gill S, Biggs P, Dearnaley D, Ardern-Jones A, Dowe A, Shearer R, McLennan DL, Norman RL, Ghadirian P, Aprikian A, Ford D, Amos C, King TM, Labrie F, Simard J, Narod SA, Easton D, Foulkes WD (1998) Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators. American Journal of Human Genetics, 62: 653-658.

  146. Labrie F, Bélanger A, Luu-The V, Labrie C, Simard J, Cusan L, Gomez JL, Candas B (1998) DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: its role during aging. Steroids, 63: 322-328.

  147. Turgeon C, Gingras S, Carrière MC, Blais Y, Labrie F, Simard J (1998) Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology, 65: 151-162.

  148. Couture P, Morissette J, Gaudet D, Vohl MC, Gagné C, Bergeron J, Després JP, Simard J (1999) Fine mapping of low-density lipoprotein receptor gene by genetic linkage on chromosome 19p13.1-p13.3 and study of the founder effect of four French Canadian low-density lipoprotein receptor gene mutations. Atherosclerosis, 143: 145-151.

  149. Gingras S, Moriggl R, Groner B, Simard J (1999) Induction of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase type I gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13. Molecular Endocrinology, 13: 66-81.

  150. Gingras S, Simard J (1999) Induction of 3β-hydroxysteroid dehydrogenase/isomerase type 1 expression by interleukin-4 in human normal prostate epithelial cells, immortalized keratinocytes, colon and cervix cancer cell lines. Endocrinology, 140: 4573-4584.

  151. Gingras S, Simard J, Groner B, Pfitzner E (1999) p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6. Nucleic Acids Research, 27: 2722-2729.

  152. Labrie F, Labrie C, Bélanger A, Simard J, Gauthier S, Luu-The V, Mérand Y, Giguère, V, Candas B, Luo S, Martel C, Singh SM, Fournier M, Coquet A, Richard V, Charbonneau R, Charpenet G, Tremblay A, Tremblay G, Cusan L, Veilleux R (1999) EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium. J. Steroid Biochem. Molec. Biol., 69: 51-84.

  153. Labrie F, Simard J, Coquet A, Leblanc G, Candas B (1999) Relative Potency of Bicalutamide (Casodex) and Flutamide (Eulexin). Urology, 54: 194-196.

  154. Moisan AM, Ricketts ML, Tardy V, Desrochers M, Mébarki F, Chaussain JL, Cabrol S, Raux-Demay MC, Forest MG, Sippell WG, Peter M, Morel Y, Simard J (1999) New Insight into the Molecular Basis of 3β-Hydroxysteriod Dehydrogenese Deficiency: Identification of Eight Mutations in the HSD3B2 Gene in Eleven Patients from Seven New Families and Comparison of the Functional Properties of Twenty-Five Mutant Enzymes. Journal of Clinical Endocrinology and Metabolism, 84: 4410-4425.

  155. Peltoketo H, Luu-The V, Simard J, Adamski J (1999) 17β-Hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes. J. Mol. Endocrinol., 23: 1-11.

  156. Tremblay MR, Simard J, Poirier D (1999) Parallel Solid-Phase Synthesis of a Model Library of 7α-Alkylamide Estradiol Derivatives as Potential Estrogen Receptor Antagonists. Bioorganic & Medicinal Chemistry Letters, 9: 2827-2832.

  157. Alos N, Moisan AM, Ward L, Desroschers M, Legault L, Leboeuf G, Van Vliet G, Simard J (2000) A novel A10E homozygous mutation in the HSD3B2 gene causing severe salt-wasting 3β–hydroxysteroid dehydrogenase deficiency in 46,XX and 46,XY French-Canadians: evaluation of gonadal function after puberty. Journal of Clinical Endocrinology and Metabolism, 85: 1968-1974.

  158. Badzioch M, Eeles R, Leblanc G, Foulkes WD, Giles G, Edwards S, Goldgar D, Hopper J, Bishop DT, Moller P, Heimdal K, Easton D, the CRC/BPG UK Familial Prostate Cancer Study Coordinators & Collaborators, the EU Biomed Collaborators, Simard J (2000) Suggestive evidence for a site specific prostate cancer gene on chromosome 1p36. Journal of Medical Genetics, 37: 947-948.

  159. Gingras S, Côté S, Simard J (2000) Multiple signaling pathways mediate interleukin-4-induced 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase type 1 gene expression in human breast cancer cells. Molecular Endocrinology, 14: 229-240.

  160. Labrie F, Luu-The V, Lin SX, Simard J, Labrie C (2000) Role of 17β–hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues. Trends in Endocrinology and metabolism, 11(10): 421-427.

  161. Labrie F, Luu-The V, Lin SX, Simard J, Labrie C, El-Alfy M, Pelletier G, Bélanger A (2000) Intracrinology: role of the family of 17β-hydroxysteroid dehydrogenases in human physiology and disease. J. Molecular Endocrinology, 25: 1-16.

  162. Simard J, Ricketts ML, Moisan AM, Tardy V, Peter M, Morel Y (2000) A new insight into the molecular basis of 3β–hydroxysteroid dehydrogenase deficiency. Endocrine Research, 26: 761-770.

  163. Singh R, Eeles RA, Durocher F, Simard J, Edwards S, Badzioch M, Teare D, Ford D, Dearnaley D, Ardern-Jones A, Murkin A, Dowe A, Shearer R, Kelly J, Labrie F, The CRC/BPG UK Familial Prostate Cancer Study Collaborators, Easton D, Narod SA, Tonin PN, Foulkes W (2000) High risk genes predisposing to prostate cancer development-do they exist? Prostate Cancer and Prostatic Diseases, 3: 241-247.

  164. The BRCA1 Exon 13 Duplication Screening Group (2000) The Exon 13 Duplication in the BRCA1 Gene Is a Founder Mutation Present in Geographically Diverse Populations. American Journal of Human Genetics, 67: 207-212.

  165. Xu J, and The International Consortium for Prostate Cancer Genetics (2000) Combined Analysis of Hereditary Prostate Cancer Linkage to 1q24-25: results from 772 Hereditary Prostate Cancer Families from the International Consortium for Prostate Cancer Genetics. American Journal of Human Genetics, 66: 945-957.

  166. Couture P, Bovill EG, Demers C, Simard J, Delage R, Scott BT, Valliere JE, Callas PW, Jomphe M, Rosendaal FR, Aiach M, Long GL (2001) Evidence of a founder effect for the protein C gene 3363 inserted C mutation in thrombophilic pedigrees of French origin. Thrombosis and Homeostasis, 86: 1000-6.

  167. Dorval M, Maunsell E, Dugas M and Simard J (2001) Support groups for people carrying a BRCA mutation. Canadian Medical Association Journal, 165: 740-741.

  168. Gingras S, Côté S, Simard J (2001) Multiple Signal transduction Pathways Mediate Interleukin-4-Induced 3β–hydroxysteroid dehydrogenase/Δ5Δ4 isomerase in normal and tumoral target tissues. J. Steroid Biochem. Molec. Biol., 76: 213-25.

  169. Labrie F, Labrie C, Bélanger A, Giguère V, Simard J, Mérand Y, Gauthier S, Luu-The V, Candas B, Martel C, Luo S (2001) Pure selective estrogen receptor modulators, new molecules having absolute cell specificity ranging from pure antiestrogenic to complete estrogen-like activities. Advances in Protein Chemistry, Vol. 56: 293-368.

  170. Labrie F, Labrie C, Bélanger A, Simard J, Giguère V, Tremblay A, Tremblay G (2001) EM-652 (SCH57068), a pure SERM having complete antiestrogenic activity in the mammary gland and endometrium. J. Steroid Biochem. Mol. Biol., 79: 213-225.

  171. Labrie F, Luu-The V, Labrie C, Simard J (2001) DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Frontiers in Neuroendocrinology, 22: 185-212.

  172. Simard J, Gingras S (2001) Crucial role of cytokines in sex steroid formation in normal and tumoral tissues. Mol. Cell. Endocrinology, 171: 25-40.

  173. Tavtigian SV, Simard J, Teng D, Abtin V, Baumgard M, Beck A, Camp NJ, Carillo AR, Chen Y, Dayananth P, Desroschers M, Dumont M, Farnham JM, Frank D, Frye C, Ghaffari S, Gupte JS, Hu R, Iliev D, Janecki T, Kort EN, Laity KE, Leavitt A, Leblanc G, McArthur-Morrison J, Pederson A, Penn B, Peterson KT, Reid JE, Richards S, Schroeder M, Smith R, Snyder SC, Swedlund B, Swensen J, Thomas A, Tranchant M, Woodland AM, Labrie F, Skolnick MH, Neuhausen S, Rommens J, Cannon-Albright L (2001) A candidate prostate cancer susceptibility gene at chromosome 17p. Nature Genetics, 27: 172-180.

  174. Callens N, Dumont M, Begue A, Lint C, Baert JL, Simard J, Launoit Y (2002) Genomic organization and identification of the promoter region of the mouse BRCA2 gene. Mammalian Genome, 13: 352-358.

  175. Carsol JL, Gingras S, Simard J (2002) Synergistic action of prolactin (PRL) and androgen on PRL-inducible protein gene expression in human breast cancer cells: A unique model for functional cooperation between signal transducer and activator of transcription-5 and androgen receptor. Molecular Endocrinology, 16: 1696-1710.

  176. Feltus A, Côté S, Simard J, Gingras S, Kovacs W, Nicholson W, Clark B, Melner M (2002) Glucocorticoids enhance activation of the human type II 3β-hydroxysteroid dehydrogenase/Δ5-Δ4ene isomerase gene. Journal of Steroid Biochemistry and Molecular Biology, 82: 55-63.

  177. Simard J, Dumont M, Soucy P, Labrie F (2002) Perspective: Prostate Cancer Susceptibility Genes. Endocrinology, 143: 2029-2040.

  178. Simard J, Moisan AM, Morel Y (2002) Congenital Adrenal Hyperplasia due to 3β-hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Deficiency. Semin Reprod Med., 20: 255-276.

  179. Gingras S, Turgeon N, Brochu N, Soucy P, Labrie F and Simard J (2003) Characterization and modulation of sex steroid metabolizing activity in normal human keratinocytes in primary culture and HaCaT cells. Journal of Steroid Biochemistry and Molecular Biology, 87: 167-179.

  180. Ginolhac S, Gad S, Corbex M, Bressac-de-Paraillets B, Chompret A, Bignon YJ, Peyrat JP, Fournier J, Lasset C, Giraud S, Muller D, Fricker JP, Hardouin A, Berthet P, Maugard C, Nogues C, Lidereau R, Longy M, Olschwang S, Toulas C, Guimbaud R, Yannoukakos D, Szabo C, Durocher F, Moisan AM, Simard J, Mazoyer S, Lynch H, Goldgar D, Stoppa-Lyonnet D, Lenoir G and Sinilnikova O (2003) BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations. Cancer Epidemiology Biomarkers and Prevention, 12:90-95.

  181. Labrie F, Cusan L, Gomez JL, Candas B, Bélanger A, Luu-the V, Labrie C, Simard J (2003) De la biologie à la clinique: le décès dû au cancer de la prostate peut-il maintenant être une exception? Medicine/Sciences, Vol. 19: 910-919.

  182. Labrie F, Luu-The V, Labrie C, Bélanger A, Simard J, Lin SX and Pelletier G (2003) Endocrine and intracrine sources of androgens in women – inhibition of breast cancer and other roles of andogens and their precursor DHEA. Endocrine Reviews, 24: 152-182.

  183. Ruel IL, Couture P, Gagné C, Deshaies Y, Simard J, Hegele RA and Lamarche B (2003) Characterization of a novel mutation causing hepatic lipase deficiency among French Canadians. Journal of Lipid Research, 44: 1508-1514.

  184. Simard J, Dumont M, Labuda D, Sinnett, D, Meloche C, El-Alfy M, Berger L, Lees E, Labrie F and Tavtigian SV (2003) Prostate Cancer Susceptibility Genes: Lessons Learned and Challenges Posed. Endocrine-Related Cancer, 10: 225-259.

  185. Simard J, Moisan AM, Calemard ML and Morel Y (2003) Males with 17β-hydroxysteroid dehydrogenase deficiency. The Endocrinologist Vol 13: 195-200.

  186. Edwards S, Meitz J, Eles R, Evans C, Easton D, Hopper J, Giles G, Foulkes WD, Narod S, Simard J, Badzioch M, Mahle L, International AC (2003) Results of a genome-wide linkage analysis in prostate cancer families ascertained through the ACTANE consortium. The Prostate, 57: 270-279.

  187. Dumont M, Frank D, Moisan AM, Tranchant M, Soucy P, Breton R, Labrie F, Tavtigian SV, Simard J (2004) Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. BBA – Gene Structure and Expression, 1679: 230-247.

  188. Knoppers BM, Joly Y, Lemmens T, Godard B, , Avard D, Clark T, Hamet P, Hoy M, Lanctôt S, Lowden S, Martin H, Maugard C, Millette Y, Simard J, Vachon MH, Zinatelli F (2004) Physiciancs, genetics and life insurance. Canadian Medical Association Journal, 170:1421-1423.

  189. Rouleau I, Chiquette J, Plante M, Simard J, Dorval M (2004) Changes in health-related behaviours following BRCA1/2 genetic testing: the case of hormone replacement therapy. Journal of Obstetrics and Gynaecology Canada, 26: 1059-1066.

  190. Szabo CI, Schutte M, Broeks A, Houwing-Duistermaat JJ, Thorstenson YR, Durocher F, Oldenburg RA, Wasielewski M, Odefrey F, Thompson D, Floore AN, Kraan J, Klijn JGM, van den Ouweland AMW, the BRCA-X Consortium, Cooperative Family Registry Breast Cancer Study, INterdisciplinary HEalth Research INternational Team on BReast CAncer susceptibility INHERIT BRCAs, Wagner TMU, Devillee P, Simard J, van’t Veer LJ, Goldgar DE, Meijers-Heijboer H (2004) Are ATM mutations 7271TG and IVS10-6TG really high-risk breast cancer-susceptibility alleles? Cancer Research, 64: 840-843.

  191. Dorval M, Gauthier G, Maunsell E, Dugas MJ Rouleau I, Chiquette J, Plante M, Laframboise R, Gaudet M, Bridge PJ, INHERIT BRCAs, Simard J (2005) No Evidence of False Reassurance Among Women With an Inconclusive BRCA1/2 Genetic Test Result. Cancer Epidemiology Biomarkers and Prevention, 14: 2862-2867.

  192. Durocher F, Sanchez R, Ricketts ML, Labrie Y, Laudet V, Simard J (2005) Characterization of the guinea pig 3b-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase expressed in the adrenal gland and gonads. Journal of Steroid Biochemistry and Molecular Biololy, 97: 289-298.

  193. Fortin J, Moisan AM, Dumont M, Leblanc G, Labrie Y, Durocher F, Bessette P, Bridge P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Provencher L, Voyer P, Simard J (2005) A new alternative splice variant of BRCA1 containing an additional in-frame exon. BBA - Gene Structure and Expression, 1731: 57-65.

  194. Gauthier S, Cloutier J, Dory YL, Favre A, Mailhot J, Ouellet C, Schwerdtfeger A, Merand Y, Martel C, Simard J, Labrie F (2005) Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution. Journal of Enzyme Inhibition and Medicinal Chemistry, 20: 165-177.

  195. Hope Q, Bullock S, Evans C, Meitz J, Hamel N, Edwards SM, Severi G, Dearnley D, Jhavar S, Southgate C, Falconer A, Dowe A, Muir K, Houlston RS, Engert JC, Roquis D, Sinnett D, Simard J, Heimdal K, Møller P, Maehle L, Badzioch M, The Cancer Research UK/British Association of Urological Surgeons’ Section of Oncology Collaborators, Eeles RA, Easton DF, English DR, Southey M, Hopper JL, Foulkes WD, Giles GG (2005) Macrophage Scavenger Receptor 1 (MSR1) 999C>T (R293X) mutation and risk of prostate cancer. Cancer Epidemiology Biomarkers and Prevention, 14: 397-402.

  196. Hughes DJ, Ginolhac SM, Coupier I, Corbex M, Bressac-de-Paillerets B, Chompret A, Bignon, YJ, Uhrhammer N, Lasset C, Giraud S, Hardouin A, Berthet P, Peyrat JP, Fournier J, Nogues C, Lidereau R, Muller D, Fricker JP, Longy M, Toulas C, Guimbaud R, Maugrad C, Olschwang S, Yannoukakos D, Durocher F, Moisan AM, Simard J, Mazoyer S, Lynch HT, Szabo C, Lenoir GM, Goldgar DE, Stoppa-Lyonnet D, Sinilnikova OM (2005) Common BRCA2 variants and modification of breast and ovarian cancer risk in BRCA1 mutation carriers. Cancer Epidemiology Biomarkers and Prevention, 14: 265-267.

  197. Labrie F, Bélanger A, Candas B, Cusan L, Gomez J, Labrie C, Luu-The V, Simard J. (2005) Gonadotropin-Releasing Hormone Agonists in the Treatment of Prostate Cancer. Endocrine Reviews, 26: 361-379.

  198. Labrie F, Luu-The V, Bélanger A, Lin SX, Simard J, Pelletier G (2005) Is dehydro-epiandrosterone a hormone? Journal of Endocrinology, 187: 169-196.

  199. Little J, Simard J (2005) CYP17 and breast cancer: no overall effect, but what about interactions? Breast Cancer Research, 7: 238-242.

  200. Martin LJ, Taniguchi H, Robert NM, Simard J, Tremblay JJ, Viger RS (2005) GATA Factors and the Nuclear Receptors, Steroidogenic Factor 1/Liver Receptor Homolog 1, Are Key Mutual Partners in the Regulation of the Human 3b-Hydroxysteroid Dehydrogenase Type 2 Promoter. Molecular Endrocrinology, 19: 2358-2370.

  201. Schaid DJ, Chang BL, The International Consortium for Prostate Cancer Genetics (2005) Description of the International Consortium for Prostate Cancer Genetics, and Failure to Replicate Linkage of Hereditary Cancer to 20q13. The Prostate 63: 276-290.

  202. Schwab KO, Moisan AM, Homoki J, Peter M, Simard J (2005) 17α-hydroxylase/17,20-lyase deficiency due to novel compound heterozygote mutations: treatment for tall stature in a female with male pseudohermaphroditism and spontaneous puberty in her affected sister. Journal of Pediatric Endocrinology and Metabolism, 18: 403-411.

  203. Simard J, Ricketts ML, Gingras S, Soucy P, Feltus A, Melner MH (2005) Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene family, Endocrine Reviews, 26: 525-582.

  204. Vallée MH, Rouleau I, Chiquette J, Plante M, Simard J and Dorval M (2005) HRT use among women tested for BRCA1/2 mutations following the publication of the women’s health initiative study results. Journal of Obstetrics Gynecology Can, 27:321.

  205. Vézina H, Durocher F, Dumont M, Houde L, Szabo C, Tranchant M, Chiquette J, Plante M, Laframboise R, Lépine J, BCLC Haplotype Group, Nevanlinna H, Stoppa-Lyonnet D, Goldgar D, Bridge P, INHERIT BRCAs and Simard J (2005) Molecular and Genealogical Characterization of the R1443X-BRCA1 Mutation in High-risk French-Canadian Breast/Ovarian Cancer Families. Human Genetics, 117: 119-132.

  206. Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Eeles RA, Easton DF, Foulkes WD, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Bishop T, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, The ACTANE Consortium, Hsieh CL, Halpern J, Balise RN, Oakley-Girvan I, Whittemore AS, Ewing CM, Gielzak M, Isaacs SD, Walsh PC, Wiley KE, Isaacs WB, Thibodeau SN, McDonnell SK, Cunningham JM, Zarfas KE, Hebbring S, Schaid, DJ, Friedrichsen DM, Deutsch K, Kolb S, Badzioch M, Jarvik GP, Janer M, Hood L, Ostrander EA, Stanford JL, Lange EM, Beebe-Dimmer JL, Mohai CE, Cooney KA, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen MP, Tammela TLJ, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel JJ, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson BA, Grönberg H, Camp NJ, Farnham J, Cannon-Albright LA, Seminara D (2005) A Combined Genomewide Linkage Scan of 1,233 Families for Prostate Cancer-Susceptibility Genes Conducted by the International Consortium for Prostate Cancer Genetics. American Journal of Human Genetics, 77: 219-229.

  207. Alamian A, Rouleau I, Simard J, Dorval M for INHERIT BRCAs (2006) Use of Dietary Supplements Among Women at High Risk of Hereditary Breast and Ovarian Cancer (HBOC) tested for Cancer Susceptibility. Nutrition and Cancer, 54: 157-165.

  208. Andrieu N, Easton DF, Chang-Claude J, Rookus MA, Brohet R, Cardis E, Antoniou AC, Wagner T, Simard J, Evans G, Peock S, Fricker JP, Nogues C, Van’t Veer L, Van Leeuwen FE, Goldgar DE (2006) Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the International BRCA1/2 Carrier Cohort Study: A Report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators’ Group. Journal of Clinical Oncology, 24: 3361-3366.

  209. Andrieu N, Goldgar DE, Easton DF, Rookus M, Brohet R, Antoniou AC, Peock S, Evans G, Eccles D, Douglas F, EMBRACE, Noguès C, Gauthier-Villars M, Chompret A, GENEPSO, Van Leeuwen FE, Kluijt I, GEO-HEBON, Benitez J, Arver B, Olah E, the IBCCS collaborators Group, Chang-Claude J (2006) Pregnancies, breast-feeding and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (IBCCS). Journal of the National Cancer Institute, 98: 535-544.

  210. Antoniou AC, Durocher F, Smith P, Simard J, INHERIT BRCAs program members, Easton DF (2006) BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high risk French-Canadian families. Breast Cancer Research, 8:R3.

  211. Avard D, Bridge P, Bucci LM, Chiquette J, Dorval M, Durocher F, Easton D, Godard B, Goldgar D, Knoppers BM, Laframboise R, Lespérance B, Plante M, Tavtigian SV, Vézina H, Wilson B, INHERIT BRCAs, Simard J (2006) Partnering in Oncogenetic Research – The INHERIT BRCAs Experience: Opportunities and Challenges. Familial Cancer, 5: 3-13.

  212. Dorval M, Drolet M, LeBlanc M, Maunsell E, Dugas MJ, Simard J (2006) Using the impact of events scale to evaluate distress in the context of genetic testing for breast cancer susceptibility. Psychological Reports, 98: 873-881.

  213. Durocher F, Labrie Y, Soucy P, Sinilnikova O, Labuda D, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Tavtigian SV, Simard J (2006) Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high risk French Canadian breast/ovarian cancer families. BMC Cancer, 6: 230.

  214. Godard B, Hurlimann T, Letendre M, Egalite N, INHERIT BRCAs. (2006) Guidelines for disclosing genetic information to family members : from development to use. Familial Cancer, 5 :103-116.

  215. Knoppers BM, Joly Y, Simard J, Durocher F (2006) The emergence of an ethical duty to disclose genetic research results: International perspectives. European Journal of Human Genetics, 14: 1170-1178.

  216. Moisan AM, Fortin J, Dumont M, Samson C, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Provencher L, Voyer P, Goldgar D, Bridge P, Simard J (2006) No evidence of BRCA1/2 genomic rearrangements in high risk French-Canadian breast/ovarian cancer families. Genetic Testing, 10: 104-115.

  217. Schaid DJ, Investigators of the International Consortium for Prostate Cancer Genetics (2006) Pooled genome linkage scan of aggressive prostate cancer: Results from the International Consortium for Prostate Cancer Genetics. Human Genetics, 120: 471-485.

  218. Spurdle AB, Antoniou AC, Kelemen L, Holland H, Peock S, Cook MR, Smith PL, Greene MH, Simard J, Plourde M, Southey MC, Godwin AK, Beck J, Miron A, Daly MB, Santella RM, Hopper JL, John EM, Andrulis IL, Durocher F, Struewing JP, Easton DF, Chenevix-Trench G, Australian Breast Cancer Family Study, Australian Jewish Breast Cancer Study, Breast Cancer Family Registry, Interdisciplinary Health Research International Team on Breast Cancer Susceptibility, The Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer, and Epidemiological Study of Familial Breast Cancer Study Collaborators (2006) The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology Biomarkers and Prevention, 15: 76-79.

  219. Antoniou AC, Sinilnikova OM, Simard J, Léoné M, Dumont M, Neuhausen SL, Struewing JP, Stoppa-Lyonnet D, Barjhoux L, Hughes DJ, Coupier I, Belotti M, Lasset C, Bonadona V, Bignon YJ, GEMO, Rebbeck TR, Wagner T, Lynch HT, Domchek SM, Nathanson KL, Garber JE, Weitzel J, Narod SA, Tomlinson G, Olopade OI, Godwin A, Isaacs C, Jakubowska A, Lubinski J, Gronwald J, Górski B, Byrski T, Huzarski T, Peock S, Cook M, Baynes C, Gray J, Daly PA, Dorkins H, EMBRACE, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Niederacher D, Deissler H, Spurdle AB, Chen X, Waddell N, Cloonan N, kConFab, Kirchhoff T, Offit K, Friedman E, Kaufmann B, Laitman Y, Galore G, Rennert G, Lejbkowicz F, Raskin L, Andrulis IL, Ilyushik E, Ozcelik H, Devilee P, Wreeswijk MPG, Greene MH, Prindiville SA, Osorio A, Benítez J, Zikan M, Szabo CI, Kilpivaara O, Nevanlina H, Hamann U, Durocher F, Arason A, Couch FJ, Easton DF, Chenevix-Trench G on behalf of the Consortium of Investigators of Modifiers of BRCA1/2 (2007) RAD51 135G>C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. American Journal of Human Genetics, 81:1186-1200.

  220. Avard D, Simard J, Horsman D, Wilson B, Meschino W, Kim Sing C, Plante M, Eisen A, Howley H (2007) Variations in rates: Why we need clinical management recommendations. (Rapid Response to: Metcalfe K et al., p. e92-8). Open Medicine, August 31st, 1: http://www.openmedicine.ca/cms/view/rapidresponsemetcalfe.

  221. Brohet RM, Goldgar DE, Easton DF, Antoniou AC, Andrieu N, Chang-Claude J, Peock S, Eeles RA, Cook M, Chu C, Noguès C, Lasset Pascaline Berthet C, Meijers-Heijboer H, Gerdes AM, Olsson H, Caldes T, van Leeuwen FE, Rookus MA (2007) Oral Contraceptives and Breast Cancer Risk in the International BRCA1/2 Carrier Cohort Study: A Report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group. Journal of Clinical Oncology, 25: 3831-3836.

  222. Chang-Claude J, Andrieu N, Rookus M, Brohet R, Antoniou AC, Peock S, Davidson R, Izatt L, Cole T, Noguès C, Luporsi E, Huiart L, Hoogerbrugge N, Van Leeuwen FE, Osorio A, Eyfjord J, Radice P, Goldgar DE, Easton DF, Epidemiological Study of Familial Breast Cancer (EMBRACE), Gene Etude Prospective Sein Ovaire (GENEPSO), Genen Omgeving studie van de werkgroep Hereditiair Borstkanker Onderzoek Nederland (GEO-HEBON), the International BRCA1/2 Carrier Cohort Study (IBCCS) collaborators group. (2007) Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study. Cancer Epidemiology Biomarkers and Prevention, 16: 740-746.

  223. Chenevix-Trench G, Milne RL, Antoniou AC, Couch FJ, Easton DF, Goldgar DE on behalf of CIMBA (2007) An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: The Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA). Breast Cancer Research, 9: 104-107.

  224. Couch FJ, Antoniou AC, Sinilnikova O, Vierkant RA, Shane Pankratz V, Fredericksen ZS, Stoppa-Lyonnet D, Coupier I, Hughes D, Hardoin A, Berthet P, GEMO, EMBRACE, Jakubowska A, Lubinski J, Spurdle AB, KConFab, Schmutzler R, Offitt K, Andrulis IL, Ilyushik E, Glennon G, Devilee P, Wreeswijk MPG, Vasen HFA, Borg A, Blackenhorn K, Struewing JP, Greene MH, Neuhausen SL, Rebbeck TR, Nathanson K, Domchek S, Wagner T, Garber JE, Szabo C, Zikan M, Foretova L, Olson JE, Sellers TA, Nevanlinna H, Tommiska J, Aittomaki K, Hamann U, Rashid MU, Torres D, Simard J, Durocher F, Guénard F, INHERIT, Lynch HT, Isaacs C, Weitzel J, Olopade OI, Narod S, Daly MB, Godwin AK, Tomlinson G, Easton DF, Chenevix-Trench G on behalf of the Consortium of Investigators of Modifiers of BRCA1/2 (2007) AURKA F31I Polymorphism and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: A CIMBA study. Cancer Epidemiology, Biomarkers and Prevention, 16 :1416-1421.

  225. Dorval M, Vallée MH, Plante M, Chiquette J, Gaudet M, INHERIT BRCAs, Simard J (2007) Effect of the women’s health initiative study publication on hormone replacement therapy use among women wo have undergone BRCA1/2 testing. Cancer Epidemiology, Biomarkers and Prevention, 16: 157-160.

  226. Durocher F, Labrie Y, Ouellette G, INHERIT BRCAs, Simard J (2007) Genetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer. Journal of Human Genetics, 52: 963-977.

  227. Godard B, Pratte A, Dumont M, Simard-Lebrun A, Simard J (2007) Factors associated with an individual’s decision to withdraw from genetic testing for breast and ovarian cancer susceptibility: Implications for counselling. Genetic Testing, 11: 45-54.

  228. Guénard F, Labrie Y, Ouellette G, Joly-Beauparlant C, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, INHERIT BRCAs, Durocher F (2007) Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families. Familial Cancer, 6: 483-490.

  229. Horsman D, Wilson BJ, Avard D, Meschino WS, Kim Sing C, Plante M, Eisen A, Howley HE, Simard J, on behalf of the National Hereditary Cancer Task Force (2007) Clinical management recommendations for surveillance and risk-reduction strategies for hereditary breast and ovarian cancer among individuals carrying a deleterious BRCA1 or BRCA2 mutation. Journal of Obstetrics and Gynaecology Canada, 29: 45-60.

  230. Plourde M, Samson C, Durocher F, INHERIT BRCAs, Simard J (2007) Characterization of HSD17B1 Sequence Variants in Breast Cancer Cases from French Canadian Families with High Risk of Breast and Ovarian Cancer. Journal of Steroid Biochemistry and Molecular Biology, 109: 115-128.

  231. Simard J, Dumont M, Moisan AM, Gaborieau V, Vézina H, Durocher F, Chiquette J, Plante M, Avard D, Bessette P, Brousseau C, Dorval M, Godard B, Houde L, Joly Y, Lajoie MA, Leblanc G, Lépine J, Lespérance B, Malouin H, Parboosingh J, Pichette R, Provencher L, Rhéaume J, Sinnett D, Samson C, Simard JC, Tranchant M, Voyer P, INHERIT BRCAs, Easton D, Tavtigian SV, Knoppers BM, Laframboise R, Bridge P, Goldgar D (2007) Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multi-step testing approach in French-Canadian high-risk breast and/or ovarian cancer families. Journal of Medical Genetics, 44: 107-121.

  232. Antoniou AC, Spurdle AB, Sinilnikova OM, Healy S, Pooley KA, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Hofmann W, Sutter C, Niederacher D, Deisler H, Caldes T, Kämpjärvi K, Nevanlinna H, Simard J, Beesley J, Chen X, The Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Heuhausen SL, Rebbeck TR, Wagner T, Lynch HT, Isaacs C, Weitzel J, Ganz PA, Daly MB, Tomlinson G, Olopade OI, Blum JL, Couch FJ, Peterlongo P, Manoukian S, Barile M, Radice P, Szabo CI, Mateus Pereira LH, Greene MH, Rennert G, Lejbkowicz F, Barnett-Griness O, Andrulis I, Ozcelik H, OCGN, Gerdes AM, Caligo MA, Laitman Y, Kaufmann B, Milgrom R, Friedman E, SWE-BRCA, Domchek SM, Nathanson KL, Osorio A, Llort G, Milne RL, Benítez J, Hamann U, Hogervorst FBL, Rookus MA, Manders P, Ligtenberg MJL, van den Ouweland AMW, Peock S, Cook M, Platte R, Evans DG, Eeles R, Pichert G, Chu C, Eccles D, Davidson R, Douglas F, EMBRACE, Godwin AK, Barjhoux L, Mazoyer S, Sobol H, Bourdon V, Eisinger F, Chompret A, Capoulade C, Bressac-de-Paillerets B, Lenoir GM, Gauthier-Villars M, Houdayer C, Stoppa-Lyonnet D, Chenevix-Trench G, Easton DF on behalf of CIMBA (2008) Common breast cancer predisposition alleles modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. American Journal of Human Genetics 82: 937-948.

  233. Desjardins S, Belleau P, Labrie Y, Ouellette G, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, INHERIT BRCAs, Durocher F (2008) Genetic variants and haplotye analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families. International Journal of Cancer, 122: 108-116.

  234. Desjardins S, Ouellette G, Labrie Y, Simard J, INHERIT BRCAs, Durocher F (2008) Analysis of GADD45A sequence variations in French Canadian families with high risk of breast cancer. Journal of Human Genetics, 53: 490-498.

  235. Dorval M, Bouchard K, Maunsell E, Plante M, Chiquette J, Camden S, Dugas M, Simard J, INHERIT BRCAs (2008) Health behaviors and psychological distress in women initiating BRCA1/2 genetic testing: comparison with control population. Journal of Genetic Counseling, 17: 314-326.

  236. Guénard F, Labrie Y, Ouellette G, Joly Beauparlant, Simard J, INHERIT BRCAs, Durocher F (2008) Mutational analysis of the breast cancer susceptibility gene BRIP1/BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families. Journal of Human Genetics, 53: 579-591.

  237. Plourde M, Manhes C, Leblanc G, Durocher F, Dumont M, INHERIT BRCAs, Simard J (2008) Mutation analysis and characterization of HSD17B2 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer. Journal of Endocrinology, 40: 161-172.

  238. Antoniou AC, Rookus M, Andrieu N, Brohet R, Chang-Claude J, Peock S, Cook M, Evans DG, Eeles R, EMBRACE, Nogues C, Faivre L, Gesta P, GENEPSO, van Leeuwen FE, Ausems MGEM, GEO-HEBON, Osorio A, Caldes T, Simard J, Lubinski J, Gerdes A-M, Olah E, Fürhauser C, Olsson H, Arver B, Radice P, Easton DF and Goldgar DE (2009) Reproductive and hormonal factors, and ovarian cancer risk among BRCA1 and BRCA2 mutation carriers: results from the International BRCA1/2 Carrier Cohort Study. Cancer Epidemiology, Biomarkers & Prevention, (Feb) 18: 601-610. PMID: 19190154.

  239. Antoniou AC, Sinilnikova OM, McGuffog L, Healey S, Nevanlinna H, Heikkinen T, Simard J, Spurdle AB, Beesley J, Chen X; The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Neuhausen SL, Ding YC, Couch FJ, Wang X, Fredericksen Z, Peterlongo P, Peissel B, Bonanni B, Viel A, Bernard L, Radice P, Szabo CI, Foretova L, Zikan M, Claes K, Greene MH, Mai PL, Rennert G, Lejbkowicz F, Andrulis IL, Ozcelik H, Glendon G; OCGN, Gerdes AM, Thomassen M, Sunde L, Caligo MA, Laitman Y, Kontorovich T, Cohen S, Kaufman B, Dagan E, Baruch RG, Friedman E, Harbst K, Barbany-Bustinza G, Rantala J, Ehrencrona H, Karlsson P, Domchek SM, Nathanson KL, Osorio A, Blanco I, Lasa A, Benítez J, Hamann U, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, van der Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, van Roozendaal CE; HEBON, Peock S, Cook M, Frost D, Oliver C, Platte R, Evans DG, Lalloo F, Eeles R, Izatt L, Davidson R, Chu C, Eccles D, Cole T, Hodgson S; EMBRACE, Godwin AK, Stoppa-Lyonnet D, Buecher B, Léoné M, Bressac-de Paillerets B, Remenieras A, Caron O, Lenoir GM, Sevenet N, Longy M, Ferrer SF, Prieur F; GEMO, Goldgar D, Miron A, John EM, Buys SS, Daly MB, Hopper JL, Terry MB, Yassin Y; Breast Cancer Family Registry, Singer CF, Gschwantler-Kaulich D, Staudigl C, Hansen TV, Barkardottir RB, Kirchhoff T, Pal P, Kosarin K, Offit K, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Schwartz PE, Blank SV, Toland AE, Montagna M, Casella C, Imyanitov EN, Allavena A, Schmutzler RK, Versmold B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Deißler H, Fiebig B, Suttner C, Schönbuchner I, Gadzicki D, Caldes T, de la Hoya M, Pooley KA, Easton DF; Georgia Chenevix-Trench; on behalf of CIMBA (2009) Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics, (Nov) 18: 4442-4456. PMID : 19656774.

  240. Desjardins S, Beauparlant JC, Labrie Y, Ouellette G, Durocher F; INHERIT BRCAs. (2009) Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2 French Canadian families with high risk of breast cancer. BMC Cancer, (Jan) 12;9:181. PMID: 19523210.

  241. Osorio A, Milne RL, Pita G, Peterlongo P, Heikkinen T, Simard J, Chenevix-Trench G, Spurdle AB, Beesley J, Chen X, Healey S; KConFab, Neuhausen SL, Ding YC, Couch FJ, Wang X, Lindor N, Manoukian S, Barile M, Viel A, Tizzoni L, Szabo CI, Foretova L, Zikan M, Claes K, Greene MH, Mai P, Rennert G, Lejbkowicz F, Barnett-Griness O, Andrulis IL, Ozcelik H, Weerasooriya N; OCGN, Gerdes AM, Thomassen M, Cruger DG, Caligo MA, Friedman E, Kaufman B, Laitman Y, Cohen S, Kontorovich T, Gershoni-Baruch R, Dagan E, Jernström H, Askmalm MS, Arver B, Malmer B; SWE-BRCA, Domchek SM, Nathanson KL, Brunet J, Ramón Y Cajal T, Yannoukakos D, Hamann U; HEBON, Hogervorst FB, Verhoef S, Gómez García EB, Wijnen JT, van den Ouweland A; EMBRACE, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Luccarini C, Evans DG, Lalloo F, Eeles R, Pichert G, Cook J, Hodgson S, Morrison PJ, Douglas F, Godwin AK; GEMO, Sinilnikova OM, Barjhoux L, Stoppa-Lyonnet D, Moncoutier V, Giraud S, Cassini C, Olivier-Faivre L, Révillion F, Peyrat JP, Muller D, Fricker JP, Lynch HT, John EM, Buys S, Daly M, Hopper JL, Terry MB, Miron A, Yassin Y, Goldgar D; Breast Cancer Family Registry, Singer CF, Gschwantler-Kaulich D, Pfeiler G, Spiess AC, Hansen TV, Johannsson OT, Kirchhoff T, Offit K, Kosarin K, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Schwartz PE, Blank SV, Toland AE, Montagna M, Casella C, Imyanitov EN, Allavena A, Schmutzler RK, Versmold B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Deissler H, Fiebig B, Varon-Mateeva R, Schaefer D, Froster UG, Caldes T, de la Hoya M, McGuffog L, Antoniou AC, Nevanlinna H, Radice P, Benítez J; CIMBA. (2009) Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA). British Journal of Cancer, (Dec) 101: 2048-2054. PMID : 19920816.

  242. Plourde M, Ferland A, Soucy P, Hamdi Y, Tranchant M, Durocher F, Sinilnikova O, The VL, Simard J (2009) Analysis of 17beta-Hydroxysteroid Dehydrogenase Types 5, 7, and 12 Genetic Sequence Variants in Breast Cancer Cases from French Canadian Families with High Risk of Breast and Ovarian Cancer. The Journal of Steroid Biochemistry and Molecular Biology, (Sep) 116: 134-153. PMID : 19460435.

  243. Rebbeck TR, Antoniou AC, Llopis TC, Nevanlinna H, Aittomäki K, Simard J, Spurdle AB, KConFab, Couch FJ, Pereira LH, Greene MH, Andrulis IL, Ontario Cancer Genetics Network, Pasche B, Kaklamani V, Breast Cancer Family Registries, Hamann U, Szabo C, Peock S, Cook M, Harrington PA, Donaldson A, Male AM, Gardiner CA, Gregory H, Side LE, Robinson AC, Emmerson L, Ellis I, EMBRACE, Peyrat J-P, Fournier J, Vennin P, Adenis C, Muller D, Fricker J-P, Longy M, Sinilnikova OM, Stoppa-Lyonnet D, GEMO, Schmutzler RK, Versmold B, Engel C, Meindl A, Kast K, Schaefer D, Froster UG, Chenevix-Trench G, and Easton DF (2009) No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study. Breast Cancer Research and Treatment, (May) 115: 185-92. PMID : 18523885.

  244. Sinilnikova OM, Antoniou AC, Simard J, Healey S, Léoné M, Sinnett D, Spurdle AB, Beesley J, Chen X; kConFab, Greene MH, Loud JT, Lejbkowicz F, Rennert G, Dishon S, Andrulis IL; OCGN, Domchek SM, Nathanson KL, Manoukian S, Radice P, Konstantopoulou I, Blanco I, Laborde AL, Durán M, Osorio A, Benitez J, Hamann U, Hogervorst FB, van Os TA, Gille HJ; HEBON, Peock S, Cook M, Luccarini C, Evans DG, Lalloo F, Eeles R, Pichert G, Davidson R, Cole T, Cook J, Paterson J, Brewer C; EMBRACE, Hughes DJ, Coupier I, Giraud S, Coulet F, Colas C, Soubrier F, Rouleau E, Bièche I, Lidereau R, Demange L, Nogues C, Lynch HT; GEMO, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Sutter C, Deissler H, Schaefer D, Froster UG; GC-HBOC, Aittomäki K, Nevanlinna H, McGuffog L, Easton DF, Chenevix-Trench G, Stoppa-Lyonnet D; Consortium of Investigators of Modifiers of BRCA1/2 (2009) The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. British Journal of Cancer, (Oct) 101: 1456-1460. PMID : 19707196.

  245. Antoniou AC, Beesley J, McGuffog L, Sinilnikova OM, Healey S, Neuhausen SL, Ding YC, Rebbeck TR, Weitzel JN, Lynch HT, Isaacs C, Ganz PA, Tomlinson G, Olopade OI, Couch FJ, Wang X, Lindor NM, Pankratz VS, Radice P, Manoukian S, Peissel B, Zaffaroni D, Barile M, Viel A, Allavena A, Dall’Olio V, Peterlongo P, Szabo CI, Zikan M, Claes K, Poppe B, Foretova L, Mai PL, Greene MH, Rennert G, Lejbkowicz F, Andrulis IL, Ozcelik H, Glendon G, Ontario Cancer Genetics Network, Thomassen M, Gerdes AM, Sunde L, Cruger D, Jensen UB, Caligo M, Friedman E, Kaufman B, Laitman Y, Milgrom R, Dubrovsky M, Cohen S, Borg A, Jernström H, Lindblom A, Rantala J, Stenmark-Askmalm M, Melin B, SWE-BRCA, Nathanson K, Domchek S, Jakubowska A, Lubinski J, Huzarski T, Osorio A, Lasa A, Durán M, Tejada MI, Godino J, Benitez J, Hamann U, Kriege M, Hoogerbrugge N, van der Luijt RB, van Asperen CJ, Devilee P, Meijers-Heijboer EJ, Blok MJ, Aalfs CM, Hogervorst F, Rookus M, HEBON, Peock S, Cook M, Oliver C, Frost D, Conroy D, Evans DG, Lalloo F, Pichert G, Davidson R, Cole T, Cook J, Paterson J, Hodgson S, Morrison PJ, Porteous ME, Walker L, Kennedy MJ, Dorkins H, EMBRACE, Godwin AK, Stoppa-Lyonnet D, de Pauw A, Mazoyer S, Bonadona V, Lasset C, Dreyfus H, Leroux D, Hardouin A, Berthet P, Faivre L, Loustalot C, Noguchi T, Sobol H, Rouleau E, Nogues C, Frénay M, Vénat-Bouvet L, GEMO Study Collaborators, Goldgar D, Hopper JL, Daly MB, Terry MB, John EM, Buys SS, Yassin Y, Miron A, Breast Cancer Family Registry, Singer CF, Dressler AC, Gschwantler-Kaulich D, Pfeiler G, Hanser TVO, Jønson L, Agnarsson BA, Kirchhoff T, Offit K, Devlin V, Dutra-Clarke A, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Schwartz JBPE, Blank SV, Ewart Toland A, Montagna M, Casella C, Imyanitov E, Tihomirova L, Blanco I, Lazaro C, Ramus SJ, Sucheston L, Karlan BY, Gross J, Schmutzler R, Wappenschmidt B, Engel C, Meindl A, Lochmann M, Arnold N, Heidemann S, Varon-Mateeva R, Niederacher D, Sutter C, Deissler H, Gadzicki D, Preisler-Adams S, Kast K, Schönbuchner I, Caldes T, de la Hoya M, Aittomäki K, Nevanlinna H, Simard J, Spurdle AB, Holland H, Chen X, kConFab, Platte R, Chenevix-Trench G and Easton DF on behalf of CIMBA. (2010) Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. Cancer Research, (Dec) 70:9742-54. PMID : 21118973.

  246. Antoniou AC, Wang X, Fredericksen ZS, McGuffog L, Tarrell R, Sinilnikova OM, Healey S, Morrison J, Kartsonaki C, Lesnick T, Ghoussaini M, Barrowdale D; EMBRACE, Peock S, Cook M, Oliver C, Frost D, Eccles D, Evans DG, Eeles R, Izatt L, Chu C, Douglas F, Paterson J, Stoppa-Lyonnet D, Houdayer C, Mazoyer S, Giraud S, Lasset C, Remenieras A, Caron O, Hardouin A, Berthet P; GEMO Study Collaborators, Hogervorst FB, Rookus MA, Jager A, van den Ouweland A, Hoogerbrugge N, van der Luijt RB, Meijers-Heijboer H, Gómez García EB; HEBON, Devilee P, Vreeswijk MP, Lubinski J, Jakubowska A, Gronwald J, Huzarski T, Byrski T, Górski B, Cybulski C, Spurdle AB, Holland H; kConFab, Goldgar DE, John EM, Hopper JL, Southey M, Buys SS, Daly MB, Terry MB, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Preisler-Adams S, Arnold N, Niederacher D, Sutter C, Domchek SM, Nathanson KL, Rebbeck T, Blum JL, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Blank SV, Friedman E, Kaufman B, Laitman Y, Milgrom R, Andrulis IL, Glendon G, Ozcelik H, Kirchhoff T, Vijai J, Gaudet MM, Altshuler D, Guiducci C; SWE-BRCA, Loman N, Harbst K, Rantala J, Ehrencrona H, Gerdes AM, Thomassen M, Sunde L, Peterlongo P, Manoukian S, Bonanni B, Viel A, Radice P, Caldes T, de la Hoya M, Singer CF, Fink-Retter A, Greene MH, Mai PL, Loud JT, Guidugli L, Lindor NM, Hansen TV, Nielsen FC, Blanco I, Lazaro C, Garber J, Ramus SJ, Gayther SA, Phelan C, Narod S, Szabo CI; MOD SQUAD, Benitez J, Osorio A, Nevanlinna H, Heikkinen T, Caligo MA, Beattie MS, Hamann U, Godwin AK, Montagna M, Casella C, Neuhausen SL, Karlan BY, Tung N, Toland AE, Weitzel J, Olopade O, Simard J, Soucy P, Rubinstein WS, Arason A, Rennert G, Martin NG, Montgomery GW, Chang-Claude J, Flesch-Janys D, Brauch H; GENICA, Severi G, Baglietto L, Cox A, Cross SS, Miron P, Gerty SM, Tapper W, Yannoukakos D, Fountzilas G, Fasching PA, Beckmann MW, Dos Santos Silva I, Peto J, Lambrechts D, Paridaens R, Rüdiger T, Försti A, Winqvist R, Pylkäs K, Diasio RB, Lee AM, Eckel-Passow J, Vachon C, Blows F, Driver K, Dunning A, Pharoah PP, Offit K, Pankratz VS, Hakonarson H, Chenevix-Trench G, Easton DF, Couch FJ (2010) A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nature Genetics, (Oct) 42:885-92. PMID : 20852631.

  247. Black L, Simard J, Knoppers B.M (2010) Genetic testing, physicians and the law : will the tortoise ever catch up with the hare? Annal Health Law 2010, (Jan) 19 :115-120. PMID : 21495558.

  248. Engel C, Versmold B, Wappenschmidt B, Simard J, EMBRACE, Easton DF, Peock S, Cook M, Oliver C, Frost D, Mayes R, Evans DG, Eeles R, Paterson J, Brewer C, McGuffog L, Antoniou AC, Stoppa-Lyonnet D, Sinilnikova OM, Barjhoux L, Frenay M, Michel C, Leroux D, Dreyfus H, Toulas C, Gladieff L, Uhrhammer N, Bignon Y-J, Meindl A, Arnold N, Varon-Mateeva R, Niederacher D, Preisler-Adams S, Kast K, Deissler H, Sutter C, Gadzicki D, Chenevix-Trench Georgia, Spurdle AB, Chen X, Beesley J, kConFab, Olsson H, Kristoffersson U, Ehrencrona H, Liljegren A, SWE-BRCA, van der Luijt RB, van Os TA, van Leeuwen FE, HEBON, Domchek SM, Rebbeck TR, Nathanson KL, Osorio A, Ramón y Cajal T, Konstantopoulou I, Benítez J, Friedman E, Kaufman B, Laitman Y, Mai PL, Greene MH, Nevanlinna H, Aittomäki K, Szabo CI, Caldes T, Couch FJ, Andrulis IL, Godwin AK, Hamann U, Schmutzler RK, on behalf of the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) (2010) Association of the Variants CASP8 D302H and CASP10 V410l with Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. Cancer Epidemiology Biomarkers Prevention, (Nov) 19:2859-2868. PMID : 20978178.

  249. Guénard F, Pedneault CS, Ouellette G, Labrie Y, Simard J; INHERIT, Durocher F (2010) Evaluation of the contribution of the three breast cancer susceptibility genes CHEK2, STK11, and PALB2 in non-BRCA1/2 French Canadian families with high risk of breast cancer. Genetic Testing and Molecular Biomarkers, (Aug) 14:515-26. PMID : 20722467.

  250. Spurdle AB, Fahey P, Chen X, McGuffog L, kConFab, Easton D, Peock S, Cook M, EMBRACE, Simard J, INHERIT, Rebbeck T, MAGIC, Antoniou AC, Chenevix-Trench G (2010) Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research Treatment, (Jul) 122:281-5. PMID : 19921428.

  251. Antoniou AC, Kartsonaki C, Sinilnikova OM, Soucy P, McGuffog L, Healey S, Lee A, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Cattaneo E, Barile M, Pensotti V, Pasini B, Dolcetti R, Giannini G, Putignano AL, Varesco L, Radice P, Mai PL, Greene MH, Andrulis IL, Glendon G, Ozcelik H, Ontario Cancer Genetics Network, Thomassen M, Gerdes A-M, Kruse TA, Jensen UB, Crüger DG, Caligo MA, Laitman Y, Milgrom R, Kaufman B, Paluch-Shimon S, Freedman E, Loman N, Harbst K, Lindblom A, Arver B, Ehrencrona H, Melin B, SWE-BRCA, Nathanson KL, Domchek SM, Rebbeck T, Jakubowska A, Lubinski J, Gronwald J, Huzarski T, Byrski T, Cybulski C, Gorski B, Osorio A, Ramón y Cajal T, Fostira F, Andrés R, Benitez J, Hamann U, Hogervorst FB, Rookus MA, Hooning MJ, Nelen MR, van der Luijt RB, van O TA, van Asperen CJ, Devilee P, Meijers-Heijboer HEJ, Gómez Garcia EB, HEBON, Peock S, Cook M, Frost D, Platte R, Leyland J, Evans DG, Lalloo F, Eeles R, Izatt L, Adlard J, Davidson R, Eccles D, Ong K, Cook J, Douglas F, Paterson J, Kennedy MJ, Miedzybrodzka Z, EMBRACE, Godwin A, Stoppa-Lyonnet D, Buecher B, Belotti M, Tirapo C, Mazoyer S, Barjhoux L, Lasset C, Leroux D, Faivre L, Bronner M, Prieur F, Nogues C, Rouleau E, Pujol P, Coupier I, Frénay M, GEMO Study Collaborators, Hopper JL, Daly MB, Terry MB, John EM, Buys SS, Yassin Y, Miron A, Goldgar D, Breast Cancer Family Registry, Singer CF, Tea M-K, Pfeiler G, Dressler BE, Hansen TVO, Jønson L, Ejlertsen B, Barkardottir RB, Kirchhoff T, Offit K, Piedmonte M, Rodriguez G, Small L, Boggess J, Blank S, Basil J, Azodi M, Ewart Toland A, Montagna M, Tognazzo S, Agata S, Imyanitov E, Janavicius R, Lazaro C, Blanco I, Pharoah PDP, Sucheston L, Karlan BY, Walsh CS, Olah E, Bozsik A, Teo SH, Seldon JL, Beattie MS, van Rensburg LJ, Sluiter MD, Diez O, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ruehl I, Varon-Mateeva R, Kast K, Deissler H, Niederacher D, Arnold N, Gadzicki D, Schönbuchner I, Caldes T, de la Hoya M, Nevanlinna H, Aittomäki K, Dumont M, Chiquette J, Tischkowitz M, Chen X, Beesley J, Spurdle AB, kConFab, Neuhausen SL, Ding YC, Fredericksen Z, Wang X, Pankratz VS, Couch F, Simard J, Easton DF and Chenevix-Trench G on behalf of CIMBA (2011) Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics, (Aug) 20:3304-3321. PMID : 21593217.

  252. Bouchard K, Dubuisson W, Simard J, Dorval M (2011) Systematic mixed-methods reviews are not ready to be assessed with the available tools. Journal of Clinical Epidemiology, (Aug) 64:926-928. PMID : 21474281.

  253. Cox DG, Simard J, Sinnett D, Hamdi Y, Soucy P, Ouimet M, Barjhoux L, Verny-Pierre C, McGuffog L, Healey S, Szabo C, Greene MH, Mai PL, Andrulis IL, Ontario Cancer Genetics Network, Thomassen M, Gerdes A-M, Caligo MA, Friedman E, Laitman Y, Kaufman B, Paluch SS, Borg Å, Karlsson P, Askmalm MS, Bustinza GB, SWE-BRCA collaborators, Nathanson K, Domchek SM, Rebbeck TR, Benítez J, Hamann U, Rookus MA, van den Ouweland AMW, Ausems MGEM, Aalfs CM, van Asperen CJ, Devilee P, Gille HJJP, HEBON, EMBRACE, Peock S, Frost D, Evans DG, Eeles R, Izatt L, Adlard J, Paterson J, Eason J, Godwin AK, Remon M-A, Moncoutier V, Gauthier-Villars M, Lasset C, Giraud S, Hardouin A, Berthet P, Sobol H, Eisinger F, Bressac-de Paillerets B, Caron O, Delnatte C, GEMO Study Collaborators, Goldgar D, Miron A, Ozcelik H, Buys S, Southey MC, Terry MB, Breast Cancer Family Registry, Singer CF, Dressler A-C, Tea M-K, van Overeem Hansen T, Johannsson O, Piedmonte M, Rodriguez GC, Basil JB, Blank S, Toland AE, Montagna M, Isaacs C, Blanco I, Gayther SA, Moysich KB, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Sutter C, Gadzicki D, Fiebig B, Caldes T, Laframboise R, Nevanlinna H, Chen X, Beesley J, Spurdle AB, Neuhausen SL, Ding YC, Couch FJ, Wang X, Peterlongo P, Manoukian S, Bernard L, Radice P, Easton DF, Chenevix-Trench G, Antoniou AC, Stoppa-Lyonnet D, Mazoyer S, Sinilnikova OM, on behalf of the Consortium of Investigators of Modifiers of BRCA1/2 (2011) Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutations carriers. Human Molecular Genetics, (Dec) 20:4732-4747. PMID : 21890493.

  254. Dorval M, Noguès C, Berthet P, Chiquette J, Gauthier-Villars M, Lasset C, Picard C, Plante M, INHERIT BRCAs, GENEPSO Cohort, Simard J, Reynier JC. (2011) Breast and ovarian cancer screening of non-carriers from BRCA1/2 mutation-positive families: 2-year follow-up of cohorts from France and Quebec. European Journal of Human Genetics, (May) 19:494-499. PMID : 21248744.

  255. Kaufman B, Laitman Y, Ziv E, Hamann U, Torres D, Lahad EL, Beeri R, Renbaum P, Jakubowska A, Lubinski J, Huzarski T, Toloczko-Grabarek A, Jaworska K, Durda K, Sprudle AB, Chenevix-Trench G, Simard J, Easton DF, Antonis A, Szabo C, Friedman E (2011) The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment, (Apr) 126:521-527. PMID : 20798986.

  256. Levesque E, Joly Y, Simard J (2011) Return of Research Results: General Principles and International Perspectives. The Journal of Law, Medicine & Ethics, (Dec) 583-592. PMID : 22084844.

  257. Mulligan AM, Couch FJ, Barrowdale D, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Robson M, Sherman M, Spurdle AB, Wappenschmidt B, Lee A, McGuffog L, Healey S, Sinilnikova OM, Janavicius R, Hansen TV, Nielsen FC, Ejlertsen B, Osorio A, Munoz-Repeto I, Duran M, Godino J, Pertesi M, Benitez J, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Cattaneo E, Bonanni B, Viel A, Pasini B, Papi L, Ottini L, Savarese A, Bernard L, Radice P, Hamann U, Verheus M, Meijers-Heijboer HE, Wijnen J, Gomez Garcia EB, Nelen MR, Kets CM, Seynaeve C, Tilanus-Linthorst MM, van der Luijt RB, van Os T, Rookus M, Frost D, Jones JL, Evans DG, Lalloo F, Eeles R, Izatt L, Adlard J, Davidson R, Cook J, Donaldson A, Dorkins H, Gregory H, Eason J, Houghton C, Barwell J, Side LE, McCann E, Murray A, Peock S, Godwin A, Schmutzler RK, Rhiem K, Engel C,Meindl A, Ruehl I, Arnold N, Niederacher D, Sutter C, Deissler H, Gadzicki D, Kast K, Preisler-Adams S, Varon-Mateeva R, Schoenbuchner I, Fiebig B, Heinritz W, Schafer D, Gevensleben H, Caux-Moncoutier V, Fassy-Colcombet M, Cornelis F, Mazoyer S, Leone M, Boutry-Kryza N, Hardouin A, Berthet P, Muller D, Fricker JP, Mortemousque I, Pujol P, Coupier I, Lebrun M, Kientz C, Longy M, Sevenet N, Stoppa-Lyonnet D, Isaacs C, Caldes T, de Al Hoya M, Heikkinen T, Aittomaki K, Blanco I, Lazaro C, Barkardottir RB, Soucy P, Dumont M, Simard J, Montagna M, Tognazzo S, D'Andrea E, Fox S, Yan M, Rebbeck TR, Olopade OI, Weitzel JN, Lynch HT,Ganz PA, Tomlinson GE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet M, Bhatia J, Kauff N, Singer CF, Tea MK, Gschwantler-Kaulich D, Fink-Retter A, Mai PL, Greene MH, Imyanitov E, O'Malley FP, Ozcelik H, Glendon G, Toland AE, Gerdes AM, Thomassen M, Kruse TA, Birk Jensen U, Skytte AB, Caligo MA, Soller M, Henriksson K, von Wachenfeldt A, Arver B, Stenmark-Askmalm M, Karlsson P, Ding YC, Neuhausen SL, Beattie M, Pharoah PD, Moysich KB, Nathanson KL, Karlan BY, Gross J, John EM, Daly MB, Buys SM, Southey MC, Hopper JL, Terry MB, Chung W, Miron AF, Goldgar D, Chenevix-Trench G, Easton DF, Andrulis IL, Antoniou AC, Family Registry BC, Embrace, Collaborators GS, Hebon, Network OC, Swe-Brca, Cimba (2011) Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers; results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Research, (Jan) 13:R110. PMID : 22053997.

  258. Ramus SJ, Kartsonaki C, Gayther SA, Pharoah PDP, Sinilnikova OM, Beesley J, Chen X, McGuffog L, Healey S, Couch FJ, Wang X, Fredericksen Z, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Roversi G, Barile M, Viel A, Allavena A, Ottini L, Papi L, Gismondi V, Capra F, Radice P, Greene MH, Mai PL, Andrulis IL, Glendon G, Ozcelik H, OCGN, Thomassen M, Gerdes AM, Kruse TA, Cruger D, Jensen UB, Caligo MA, Olsson H, Kristoffersson U, Lindblom A, Arver B, Karlsson P, Stenmark Askmalm M, Borg A, Neuhausen S, Ding YC, Nathanson KL, Domchek SM, Jakubowska A, Lubiński J, Huzarski T, Byrski T, Gronwald J, Górski B, Cybulski C, Dębniak T, Osorio A, Durán M, Tejada MI, Benítez J, Hamann U, Rookus MA, Verhoef S, Tilanus-Linthorst MA, Vreeswijk MP, Bodmer D, Ausems M G.E.M., van Os TA, Asperen CJ, Blok MJ, Meijers-Heijboer HEJ, HEBON, EMBRACE, Peock S, Cook M, Oliver C, Frost D, Dunning AM, Evans DG, Eeles R, Pichert G, Cole T, Hodgson S, Brewer C, Morrison PJ, Porteous M, Kennedy MJ, Rogers MT, Side LE, Donaldson A, Gregory H, Godwin A, Stoppa-Lyonnet D, Moncoutier V, Castera L, Mazoyer S, Barjhoux L, Bonadona V, Leroux D, Faivre L, Lidereau R, Nogues C, Bignon YJ, Prieur F, Collonge-Rame MA, Venat-Bouvet L, Fert Ferrer S, GEMO Study Collaborators, Miron A, Buys SS, Hopper JL, Daly MB, John E, Terry MB, Goldgar D, BCFR, Hansen TVO, Jønson L, Ejlertsen B, Agnarsson BA, Offit K, Kirchhoff T, Vijai J, Dutra-Clarke AVC, Przybylo JA, Montagna M, Casella C, Imyanitov EN, Janavicius R, Blanco I, Lázaro C, Moysich KB, Karlan BY, Gross J, Beattie MS, Schmutzler R, Wappenschmidt B, Meindl A, Ruehl I, Fiebig B, Sutter C, Arnold N, Deissler H, Varon-Mateeva R, Kast K, Niederacher D, Gadzicki D, Caldes T, de la Hoya M, Nevanlinna H, Aittomäki K, Simard J, Soucy P, kConFab Investigators, Spurdle AB, Holland H, Chenevix-Trench G, Easton DF, Antoniou AC on behalf of Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) (2011) Genetic Variation at 9p22.2 and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers. Journal of the National Cancer Institute, (Jan) 103:105-116. PMID : 21169536.

  259. Antoniou AC, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, McGuffog L, Lee A, Barrowdale D, Healey S, Sinilnikova OM, Caligo MA, SWE-BRCA, Loman N, Harbst K, Lindblom A, Arver B, Rosenquist R, Karlsson P, Nathanson K, Domchek S, Rebbeck T, Jakubowska A, Lubinski J, Jaworska K, Durda K, Złowocka E, Osorio A, Durán M, Andrés R, Benítez J, Hamann U, Hogervorst FB, van O TA, Verhoef S, Meijers-Heijboer HEJ, Wijnen J, Gómez Garcia EB, Ligtenberg MJ, Kriege M, Collée JM, Ausems MGEM, Oosterwijk JC, HEBON, EMBRACE, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lalloo F, Jacobs C, Eeles R, Adlard J, Davidson R, Cole T, Cook J, Paterson J, Douglas F, Brewer C, Hodgson S, Morrison PJ, Walker L, Rogers MT, Donaldson A, Dorkins H, Godwin AK, Bove B, Stoppa-Lyonnet D, Houdayer C, Buecher B, de Pauw A, Mazoyer S, Verny-Pierre C, Léoné M, Bressac de Paillerets B, Caron O, Sobol H, Frenay M, Prieur F, Fert Ferrer S, Mortemousque I, GEMO Study Collaborators, Buys S, Daly M, Miron A, Terry MB, Hopper JL, John EM, Southey M, Goldgar D, Singer CF, Fink-Retter A, Tea M-K, Geschwantler Kaulich D, v. O. Hansen T, Nielsen FC, Barkardottir RB, Gaudet M, Kirchhoff T, Joseph V, Dutra-Clarke A, Offit K, Piedmonte M, Kirk J, Cohn D, Hurteau J, Byron J, Fiorica J, Toland AE, Montagna M, Oliani C, Imyanitov E, Isaacs C, Tihomirova L, Blanco I, Lazaro C, Teulé A, Del Valle J, Gayther SA, Odunsi K, Gross J, Karlan BY, Olah E, Teo S-H, Ganz PA, Beattie MS, Dorfling CM, van Rensburg EJ, Diez O, Kwong A, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Heidemann S, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Fiebig B, Schäfer D, Caldes T, de la Hoya M, Nevanlinna H, Muranen TA, Lespérance B, Spurdle AB, kConFab Investigators, Neuhausen SL, Ding YC, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Radice P, Greene MH, Loud JT, Andrulis IL, Ozcelik H, Mulligan AM, Glendon G, Thomassen M, Gerdes A-M, Jensen UB, Skytte A-B, Kruse TA, Chenevix-Trench G, Couch FJ, Simard J, Easton DF on behalf of CIMBA (2012) Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Research. (Jan) 20:14:R33. PMID : 22348646.

  260. Bacha O, Plante M, Gregoire J, Grondin K, Laframboise R, Simard J (2012) Effectiveness of Risk Reducing Salpingo-Oophorectomy in preventing Ovarian Cancer in French Canadian BRCA mutation Carriers. International Journal Gynecologic Cancer, (Jul) 22:974-978. PMID : 22740003.

  261. Black L, Simard J, Knoppers BM (2012) Legal Liability and the Uncertain Nature of Prediction: The Case of Breast Cancer Risk Prediction Models. Public Health Genomics, (Jan) 15:335-40. PMID : 22987123.

  262. Couch FJ, Gaudet MM, Antoniou AC, Ramus SJ, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, Wang X, Kirchhoff T, McGuffog L, Barrowdale D, Lee A, Healey S, Sinilnikova OM, Andrulis IL, Ozcelik H, Mulligan AM, OCGN, Thomassen M, Gerdes AM, Jensen UB, Skytte A-B, Kruse TA, Caligo MA, SWE-BRCA, von Wachenfeldt A, Barbany-Bustinzan G, Loman N, Soller M, Ehrencrona H, Karlsson P, Nathanson K, Rebbeck T, Domchek S, Jakubowska A, Lubinski J, Jaworska K, Durda K, Złowocka E, Huzarski T, Byrski T, Gronwald J, Cybulski C, Górski B, Osorio A, Durán M, Tejada MI, Benitez J, Hamann U, Hogervorst FBL, van Os TA, van Leeuwen FE, Meijers-Heijboer HEJ, Wijnen J, Blok MJ, Kets M, Hooning MJ, Oldenburg RA, Ausems MGEM, HEBON, EMBRACE, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Jacobs C, Eeles R, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Paterson J, Brewer C, Douglas F, Hodgson S, Morrison PJ, Walker L, Porteous ME, Kennedy MJ, Side LE, Bove B, Godwin AK, GEMO Study Collaborators, Stoppa-Lyonnet D, Fassy-Colcombet M, Castera L, Cornelis F, Mazoyer S, Léoné M, Boutry-Kryza N, Bressac de Paillerets B, Caron O, Pujol P, Coupier I, Delnatte C, Akloul L, Lynch HT, Snyder CL, Buys SS, Daly MB, Terry MB, Chung W, John EM, Miron A, Southey MC, Hopper JL, Goldgar D, Singer CF, Rappaport C, Tea M M-K, Fink-Retter A, Hansen TVO, Nielsen FC, Arason A, Vijai J, Shah S, Sarrel K, Robson M, Piedmonte M, Phillips K, Basil J, Rubinstein W, Boggess J, Wakeley K, Ewart Toland A, Montagna M, Agata S, Imyanitov E, Isaacs C, Janavicius R, Lazaro C, Blanco I, Feliubadalo L, Brunet J, Gayther SA, Pharoah PPD, Odunsi K, Karlan BY, Walsh CS, Olah E, Teo SH, Ganz PA, Beattie MS, van Rensburg EJ, Dorfling CM, Diez O, Kwong A, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Heidemann S, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Fiebig B, Heinritz W, Caldes T, de la Hoya M, Muranen TA, Nevanlinna H, Tischkowitz M, Spurdle AB, kConFab investigators, Neuhausen SL, Ding YC, Lindor N, Fredericksen X, Pankratz VS, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Barile M, Bernard L, Viel A, Giannini G, Varesco L, Radice P, Greene MH, Mai PL, Easton DF, Chenevix-Trench G, Offit K, Simard J (2012) Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer, Epidemiology, Biomarkers & Prevention, (Apr) 21:645-657. PMID : 22351618.

  263. Ding YC, McGuffog L, Healey S, Friedman E, Laitman Y, Paluch-Shimon S, Kaufman B; for SWE-BRCA, Liljegren A, Lindblom A, Olsson H, Kristoffersson U, Stenmark-Askmalm M, Melin B, Domchek SM, Nathanson KL, Rebbeck TR, Jakubowska A, Lubinski J, Jaworska K, Durda K, Gronwald J, Huzarski T, Cybulski C, Byrski T, Osorio A, Cajal TR, Stavropoulou AV, Benítez J, Hamann U; for HEBON, Rookus M, Aalfs CM, de Lange JL, Meijers-Heijboer HE, Oosterwijk JC, van Asperen CJ, Gómez García EB, Hoogerbrugge N, Jager A, van der Luijt RB; for EMBRACE, Easton DF, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lalloo F, Izatt L, Eeles R, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Brewer C, Tischkowitz M, Godwin AK, Pathak H; for GEMO Study Collaborators, Stoppa-Lyonnet D, Sinilnikova OM, Mazoyer S, Barjhoux L, Léoné M, Gauthier-Villars M, Caux-Moncoutier V, de Pauw A, Hardouin A, Berthet P, Dreyfus H, Ferrer SF, Collonge-Rame MA, Sokolowska J, Buys S, Daly M, Miron A, Terry MB, Chung W, John EM, Southey M, Goldgar D, Singer CF, Tea MK, Gschwantler-Kaulich D, Fink-Retter A, Hansen TV, Ejlertsen B, Johannsson OT, Offit K, Sarrel K, Gaudet MM, Vijai J, Robson M, Piedmonte MR, Andrews L, Cohn D, Demars LR, Disilvestro P, Rodriguez G, Toland AE, Montagna M, Agata S, Imyanitov E, Isaacs C, Janavicius R, Lazaro C, Blanco I, Ramus SJ, Sucheston L, Karlan BY, Gross J, Ganz PA, Beattie MS, Schmutzler RK, Wappenschmidt B, Meindl A, Arnold N, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Nevanlinna H, Aittomäki K, Simard J; for KConFab Investigators, Spurdle AB, Beesley J, Chen X, Tomlinson GE, Weitzel J, Garber JE, Olopade OI, Rubinstein WS, Tung N, Blum JL, Narod SA, Brummel S, Gillen DL, Lindor N, Fredericksen Z, Pankratz VS, Couch FJ, Radice P, Peterlongo P, Greene MH, Loud JT, Mai PL, Andrulis IL, Glendon G, Ozcelik H; for OCGN, Gerdes AM, Thomassen M, Jensen UB, Skytte AB, Caligo MA, Lee A, Chenevix-Trench G, Antoniou AC, Neuhausen SL; on behalf of Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). (2012) A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers. Cancer, Epidemiology, Biomarkers & Prevention, (Aug) 21:1362-70. PMID : 22729394.

  264. Jakubowska A, Rozkrut D, Antoniou A, Hamann U, Scott RJ, McGuffog L, Healy S, Sinilnikova OM, Rennert G, Lejbkowicz F, Flugelman A, Andrulis IL, Glendon G, Ozcelik H, OCGN, Thomassen M, Paligo M, Aretini P; SWE-BRCA, Kantala J, Aroer B, von Wachenfeldt A, Liljegren A, Loman N, Herbst K, Kristoffersson U, Rosenquist R, Karlsson P, Stenmark-Askmalm M, Melin B, Natanson KL, Domchek SM, Byrski T, Huzarski T, Gronwald J, Menkiszak J, Cybulski C, Serrano P, Osorio A, Ramóny Cajal T, Tsitlaidou M, Benítez J, Gilbert M, HEBON, Rookus M, Aalfs CM, Kluijt I, Boessenkool-Pape JL, Meijers-Heijboer HEJ, Oosterwijk JC, van Asperen CJ, Blok MJ, Nelen MR, van den Ouweland AMW, Seynaeve C, van der Luijt RB, Devilee P, EMBRACE, Easton DF, Peock S, Frost D, Platte R, Eblis SD, Fineberg E, Evans DG, Lalloo F, Eeles R, Jacobs C, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Godwin A, Bove B, GEMO Study Collaborators, Stoppa-Lyonnet D, Caux-Moncoutier V, Belotti M, Tirapo C, Mazoyer S, Barjhoux L, Boutry-Kryza N, Pujol P, Coupier I, Peyrat J-P, Vennin P, Muller D, Fricker J-P, Venat-Bouvet L, Johannsson O Th., Isaacs C, Schmutzler R, Wappenschmidt B, Meindl A, Arnold N, Varon-Mateeva R, Niederacher D, Sutter C, Deissler H, Preisler-Adams S, Simard J, Soucy P, Durocher F, Chenevix-Trench G, Beesley J, Chen X, kConFab, Rebbeck T, Couch F, Wang X, Lindor N, Fredericksen Z, Pankratz VS, Peterlongo P, Bonanni B, Fortuzzi S, Peissel B, Szabo C, Mai PL, Loud JT, Lubinski J on behalf of CIMBA, the Consortium of Investigators of Modifiers of BRCA1/2-Related Cancer (2012) Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. British Journal of Cancer, (Jun) 106: 2016-24. PMID : 22669161.

  265. Lapointe J, Abdous B, Camden S, Bouchard K, Goldgar D, Simard J, Dorval M (2012) Influence of the family cluster effect on psychosocial variables in families undergoing BRCA1/2 genetic testing for cancer susceptibility. Psychooncology, (May) 21:515-23. PMID : 21370312.

  266. Lapointe J, Bouchard K, Patenaude AF, Maunsell E, INHERIT, Simard J, Dorval M (2012) Incidence and predictors of positive and negative effects of BRCA1/2 genetic testing on familial relationships: A 3-year follow-up study. Genetics in Medicine, (Jan) 14:60-8. PMID : 22237432.

  267. Larouche G, Bouchard K, Chiquette J, Desbiens C, Simard J, Dorval M (2012) Self-reported mammography use following BRCA1/2 genetic testing may be overestimated. Familial Cancer, (Mar) 11:27-32. PMID : 22080962.

  268. Mavaddat N, Barrowdale D, Andrulis IA, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Spurdle A, Robson M, Sherman M, Mulligan AM, Couch FJ, Engel C, McGuffog L, Healey S, Sinilnikova OM, Southey MC, Terry MB, Goldgar D, O’Malley F, John EM, Ramunas J, Tihomirova L, v O Hansen T, Nielsen FC, Osorio A, Stavropoulou A, Benítez J, Manoukian S, Peissel B, Barile M, Volorio S, Pasini B, Dolcetti R, Putignano AL, Ottini L, Radice P, Hamann U, Rashid MU, Hogervorst FB, Kriege M, van der Luijt RB, HEBON, EMBRACE, Peock S, Frost D, Evans DG, Brewer C, Walker L, Rogers MT, Side LE, Houghton C, Weaver JO, Godwin AK, Schmutzler RK, Wappenschmidt B, Meindl A, Kast K, Arnold N, Niederacher D, Sutter C, Deissler H, Gadzicki D, Preisler-Adams S, Varon-Mateeva R, Schönbuchner I, Gevensleben H, GEMO Study Collaborators, Stoppa-Lyonnet D, Belotti M, Barjhoux L, Isaacs C, Peshkin BN, Caldes T, de al Hoya M, Cañadas C, Heikkinen T, Heikkilä P, Aittomäki K, Blanco I, Lazaro C, Brunet J, Agnarsson BA, Arason A, Barkardottir RB, Dumont M, Simard J, Montagna M, Agata S, D’Andrea E, Yan M, Fox S, kConFab Investigators75, Rebbeck TR, Rubinstein W, Tung N, Garber JE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet MM, Singer CF, Tea M-K, Rappaport C, Mai PL, Greene MH, Sokolenko A, Imyanitov E, Toland AE, Senter L, Sweet K, Thomassen M, Gerdes A-M, Kruse T, Caligo M, Aretini P, Rantala J, von Wachenfeld A, Henriksson K, SWE-BRCA Collaborators, Steele L, Neuhausen SL, Nussbaum B, Beattie M, Odunsi K, Sucheston L, Gayther SA, Nathanson K, Gross J, Walsh C, Karlan B, Chenevix-Trench G, Easton DF, Antoniou AC on behalf of the Consortium of Investigators of Modifiers of BRCA1/2 (2012) Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer, Epidemiology, Biomarkers & Prevention, (Jan) 21:134-147. PMID : 22144499.

  269. Ouimet M, Cassart P, Larivière M, Kritikou EA, Simard J, Sinnett D (2012) Functional analysis of promoter variants in KU70 and their role in cancer susceptibility. Genes Chromosomes Cancer, (Nov) 51:1007-13. PMID : 22833453.

  270. Ramus SJ, Antoniou AC, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, McGuffog L, Sinilnikova OM, Healey S, Barrowdale D, Lee A, Thomassen M, Gerdes AM, Kruse TA, Jensen UB, Skytte A-B, Caligo MA, Liljegren A, Lindblom A, Olsson H, Kristoffersson U, Stenmark-Askmalm M, Melin B, SWE-BRCA, Domchek SM, Nathanson KL, Rebbeck TR, Jakubowska A, Lubinski J, Jaworska K, Durda K, Zlowocka E, Gronwald J, Huzarski T, Byrski T, Cybulski C, Toloczko-Grabarek A, Osorio A, Benitez J, Duran M, Tejada MI, Hamann U, Rookus M, van Leeuwen FE, Aalfs CM, Meijers-Heijboer HEJ, vans Asperen CJ, van Roozendaal KEP, Hoogerbrugge N, Collée JM, Kriege M, van der Luijt RB, HEBON, EMBRACE, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lallo F, Jacobs C, Eeles R, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Paterson J, Douglas F, Brewer C, Hodgson S, Morrison PJ, Walker L, Porteous ME, Kennedy J, Pathak H, Godwin AK, Stoppa-Lyonnet D, Caux-Moncoutier V, de Pauw A, Gauthier-Villars M, Mazoyer S, Léoné M, Calender A, Lasset C, Bonadona V, Hardouin A, Berthet P, Bignon Y-J, Uhrhammer N, Faivre L, Loustalot C, Buys S, Daly M, Miron A, Terry MB, Chung W, John EM, Southey M, Goldgar D, Singer CF, Tea Maria M-K, Pfeiler G, Fink-Retter Anneliese, v. O. Hansen T, Ejlertsen B, Johannsson OT, Offit K, Kirchhoff T, Gaudet MM, Vijai J, Robson M, Piedmonte M, Phillips K-A, Van Le L, Hoffman JS, Toland AE, Montagna M, Tognazzo S, Imyanitov E, Isaacs C, Janavicius R, Lazaro C, Blanco I, Tornero E, Navarro M, Moysich KB, Karlan BY, Gross J, Olah E, Teo S-H, Ganz PA, Beattie MS, Dorfling CM, van Rensburg EJ, Diez O, Kwong A, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Heidemann S, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Fiebig B, Schäfer D, Caldes T, de la Hoya M, Nevanlinna H, Aittonäki K, Plante M, Spurdle AB, kConFab, Neuhausen SL, Ding YC, Wang X, Lindor N, Fredericksen Z, Pankratz VS, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Bonanni B, Bernard L, Dolcetti R, Papi L, Ottini L, Radice P, Greene MH, Mai PL, Andrulis IL, Glendon G, Ozcelik H, OCGN, Pharoah PDP, Gayther SA, Simard J, Easton DF, Cough FJ, Chenevix-Trench G on behalf of the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) (2012) Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 Mutation carriers. Human Mutation, (Apr) 33:690-702. PMID : 22253144.

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PAPER(S) IN PRESS

  1. Lee AJ, Cunningham AP, Tischkowitz M, Simard J, Pharoah PD, Easton DF, Antoniou AC (2016) Incorporating Truncating Variants in PALB2, CHEK2 and ATM into the BOADICEA Breast Cancer Risk Model. Genetics in Medicine.

  2. Larouche G, Chiquette J, Plante M, Simard J, Dorval M (2015) Usefulness of Canadian public health insurance administrative databases to assess breast and ovarian cancer screening imaging technologies for BRCA1/2 mutation carriers. Canadian Association of Radiologists Journal.

  3. Shi J, Yanfeng Zhang1†, Wei Zheng1, Kyriaki Michailidou2, Maya Ghoussaini3, Manjeet K. Bolla2, Qin Wang2, Joe Dennis3, Michael Lush3, Roger L. Milne4,5, Xiao-Ou Shu1, Jonathan Beesley6, Siddhartha Kar3, Irene L. Andrulis7,8, Hoda Anton-Culver9, Volker Arndt10, Matthias W. Beckmann11, Zhiguo Zhao1, Xingyi Guo1, Javier Benitez12,13, Alicia Beeghly-Fadiel1, William Blot1,14, Natalia V. Bogdanova15, Stig E. Bojesen16,17,18, Hiltrud Brauch19,20,21, Hermann Brenner10,21,22, Louise Brinton23, Annegien Broeks24, Thomas Brüning25, Barbara Burwinkel26,27, Hui Cai1, Sander Canisius28, Jenny Chang-Claude29, Ji-Yeob Choi30,31, Fergus J. Couch32, Angela Cox33, Simon S. Cross34, Kamila Czene35, Hatef Darabi35, Peter Devilee36,37, Arnaud Droit38, Thilo Dork39, Peter A. Fasching11,40, Olivia Fletcher41, Henrik Flyger42, Florentia Fostira43, Valerie Gaborieau44, Montserrat García-Closas41,45, Graham G. Giles4,5, Mervi Grip46, Pascal Guenel47,48, Christopher A. Haiman49, Ute Hamann50, Mikael Hartman51,52, Hui Miao51, Antoinette Hollestelle53, John L. Hopper54, Chia-Ni Hsiung55, kConFab Investigators56, Hidemi Ito57, Anna Jakubowska58, Nichola Johnson41,Diana Torres50,59, Maria Kabisch50, Daehee Kang30,31,60, Sofia Khan61, Julia A. Knight62,63, Veli-Matti Kosma64, Diether Lambrechts65,66, Jingmei Li35, Annika Lindblom67, Artitaya Lophatananon68, Jan Lubinski58, Arto Mannermaa64, Siranoush Manoukian69, Loic Le Marchand70, Sara Margolin71, Frederik Marme72,73, Keitaro Matsuo74, Catriona McLean75, Alfons Meindl54, Kenneth Muir68,76, Susan L. Neuhausen77, Heli Nevanlinna61, Silje Nord78,79, Anne-Lise Børresen-Dale78,79, Janet E. Olson80, Nick Orr81, Ans M.W. van den Ouweland82, Paolo Peterlongo83, Thomas Choudary Putti84, Anja Rudolph29, Suleeporn Sangrajrang85, Elinor J. Sawyer86, Marjanka K. Schmidt24, Rita K. Schmutzler87,88,89,90, Chen-Yang Shen91,92, Ming-Feng Hou93, Matha J Shrubsole1, Melissa C. Southey94, Anthony Swerdlow95, Soo Hwang Teo96,97, Bernard Thienpont65,66, Amanda E. Toland98, Robert A.E.M. Tollenaar99, Ian Tomlinson100, Therese Truong47,48, Chiu-chen Tseng49, Wanqing Wen1, Robert Winqvist101,102, Anna H. Wu49, Cheng Har Yip97, Pilar M. Zamora103, Ying Zheng104, Giuseppe Floris105, Ching-Yu Cheng106, Maartje J. Hooning107, John W.M. Martens107, Caroline Seynaeve108, Vessela N. Kristensen78,79,109, Per Hall35, Paul D.P. Pharoah2, Simard J, Chenevix-Trench G, Dunning AM, Antoniou AC, Easton DF, Cai Q, Long J (2016) Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. International Journal Cancer.



REFEREED BOOK CHAPTERS

  1. Labrie F, Proulx L, Giguère V, Marchetti B, Godbout M, Simard J (1984) Steroid modulation of LHRH action. In: Steroid modulation of neuroendocrine function of steroids. Steroids and bone metabolism (L Martini, GS Gordon and F Sciarra, eds), Biochemical Press, 23-37.

  2. Labrie F, Dupont A, Bélanger A, Cusan L, Giguère M, Lacourcière Y, Luthy I, Bégin D, Labrie C, Simard J, Monfette G, Emond J (1987) Combination therapy in stage C and D prostatic cancer: rationale and 5-year clinical experience. In: Cancer and Metastatic Reviews (G Poste and IJ Fidler, eds), Martinus Nijhoff Publishing, 6: 615-636.

  3. Labrie F, Giguère V, Meunier H, Simard J, Gossard F, Raymond V (1987) Multiple factors controlling ACTH secretion at the anterior pituitary level. Annals of the New York Academy Sciences, 512: 97-114.

  4. Labrie F, Luthy I, Veilleux R, Simard J, Bélanger A, Dupont A (1987) New concepts on the androgen sensitivity of prostate cancer. In: Progress in clinical and biological research. Prostate cancer Part A: Research. Endocrine treatment and histopathology (GP Murphy, S Khoury, R Kuss, C Chatelain, L Denis, eds), vol. 243A: 145-172.

  5. Labrie F, Poulin R, Simard J, Hubert JF, Spinola P, Marchetti B (1987) Adrenal steroids exert potent estrogen action in both normal and cancer tissue. In: Hormonal Manipulation of Cancer: Peptides Growth Factors and New (Anti-)Steroidal Agents. Monograph Series of the European Organization for Research on Treatment of Cancer (JGM Klijn, R Paridaens and JA Foekens, eds), Raven Press 18: 7-16.

  6. Labrie F, Dupont A, Bélanger A, Simard J, Labrie C, Poulin R, Luthy I, Veilleux R, Lacoste D, Marchetti B, Cusan L, Manhès G, Monfette G, Emond J (1988) Combination therapy with the antiandrogen Flutamide and the LHRH agonist [D-Trp6, des-Gly-NH210]LHRH ethylamide in prostate cancer: rationale and 5-year clinical experience. In: Molecular Biology of Brain and Endocrine Peptidergic Systems (KW McKerns, ed), Plenum Press 83-101.

  7. Labrie F, Simard J, Labrie C, Hubert JF, Barden N, Gagné B (1988) Modulation of α-subunit and LHβ-mRNA in the rat anterior pituitary gland by sex steroids and an LHRH agonist. In: Recent Research on Gynecological Endocrinology (AR Genazzani, F Petraglia, A Volé and F Facchinetti, eds), 1: 15-22.

  8. Vincens M, Simard J, De Lignières B (1988) Androgènes. In: Pharmacologie clinique. Base de la thérapeutique (JP Giroud, G Mathé and G Meyniel, eds), 2e édition, Expansion Scientifique (Paris), 2139-2158.

  9. Labrie C, Simard J, Marchetti B, Pelletier G, Zhao HF, Bélanger A, Labrie F (1989) Conversion of precursor adrenal steroids into potent androgens in peripheral tissue. In: Early Stage Prostate Cancer: Diagnosis and Choice of Therapy (F Labrie, F Lee, A Dupont, eds), Elsevier, ICS 841: 1-22.

  10. Pelletier G, Tong Y, Simard J, Zhao HF, Labrie F (1989) Localization of peptide gene expression by in situ hybridization at the electron microscopic level. In: Methods in Neurosciences (Conn M, ed), Academic Press 1: 197-208.

  11. Labrie C, Simard J, Poulin M, Bélanger A, Pelletier G, Labrie F (1990) Influence of the duration of androgen deprivation on the sensitivity of the rat ventral prostate to dehydroepiandrosterone and androstenedione. In: Steroid Formation, Degradation and Action in Peripheral Tissues (H Bradlow, L Castagnetta, S d'Aquino and F Labrie, eds), Annals of the New York Academy Sciences, 595: 392-394.

  12. Labrie C, Simard J, Zhao HF, Bélanger A, Pelletier G, Labrie F (1990) Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate. In: Steroid Formation, Degradation and Action in Peripheral Tissues (H Bradlow, L Castagnetta, S d'Aquino and F Labrie, eds), Annals of the New York Academy Sciences, 595: 395-398.

  13. Labrie F, Poulin R, Simard J, Zhao HF, Labrie C, Dauvois S, Dumont M, Hatton AC, Poirier D, Mérand Y (1990) Interactions between estrogens, androgens, progestins and glucocorticoids in ZR-75-1 human breast cancer cells. Annals of the New York Academy Sciences, 595: 130-148.

  14. Labrie F, Simard J, Poulin R, Hatton AC, Labrie C, Dauvois S, Zhao HF, Petitclerc L, Couët J, Dumont M (1990) Potent antagonism between estrogens and androgens on GCDFP-15 expression and cell growth in the ZR-75-1 human breast cancer cells. In: Workshop on Biochemistry of Breast Cyst Fluid and Cancer Risk (A Angeli, H Bradlow, FI Chasalow and L Dogliotti, eds), Annals of the New York Academy Sciences, 586: 174-187.

  15. Luu-The V, Labrie C, Zhao HF, Couët J, Lachance,Y, Simard J, Côté J, Leblanc G, Lagacé L, Bérubé D, Gagné R, Labrie F (1990) Purification, cloning, complementary DNA structure and predicted amino acid sequence of human estradiol 17β-dehydrogenase. In: Steroid Formation, Degradation and Action in Peripheral, Normal and Neoplastic Tissues (H Bradlow, L Castagnetta, S d'Aquino and F Labrie, eds), Annals of the New York Academy Sciences, 595: 40-52.

  16. Simard J, Labrie C, Mérand Y, Dufour JM, Lévesque C, Labrie F (1990) Pure antagonistic effect of a new steroidal antiestrogen in rat anterior pituitary cells in culture and in mouse uterus. In: Steroid Formation, Degradation and Action in Peripheral Tissues (H Bradlow, L Castagnetta, S d'Aquino and F Labrie, eds), Annals of the New York Academy Sciences, 595: 425-427.

  17. Labrie F, Simard J, Luu-The V, Bélanger A, Cusan L, Dupont A, Trudel C, Martel C, Labrie C, Zhao HF, Dupont E, Couët J, Lachance Y, Dumont M, de Launoit Y, Breton N (1991) Androgens in post-menopause. In: Rivista di Ostetricia e Ginecologia Pratica e Medicina Perinatale Palermo, 1: 15-24.

  18. Simard J, Zhao HF, Labrie C, Trudel C, Rhéaume E, Dupont E, Breton N, Luu-The V, Pelletier G, Labrie F (1991) Molecular cloning of rat 3β-HSD: structure of two types of cDNAs and differential expression of corresponding mRNAs in the ovary. In: Signaling Mechanisms and Gene Expression in the Ovary. Serono Symposia, Springer-Verlag, New York, 274-279.

  19. Labrie F, Simard J, Luu-The V, Pelletier G, Bélanger A (1992) Cloning, expression and regulation of tissue-specific expression of 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase. In: Cellular and Molecular Biology of the Adrenal Cortex, John Libbey Eurotext Ltd, 222: 89-109.

  20. de Launoit Y, Simard J, Zhao HF, Couture, P, Labrie F (1993) Structure-function relationships of multiple rat members of the 3β-hydroxysteroid dehydrogenase family. In: Molecular Basis of Reproductive Endocrinology (Leung PCK, Hsueh AJW, Friesen HG, Eds), New York, Springer-Verlag, 201-209.

  21. Labrie F, Simard J, Luu-The V, Pelletier G, Labrie C, Dupont E, Martel C, Couët J, Trudel C, Rhéaume E, Breton N, de Launoit Y, Dumont M, Zhao HF, Lachance Y (1993) Structure and control of expression of the 3β-HSD and 17β-HSD genes in classical steroidogenic and peripheral intracrine tissues. In: Molecular Basis of Reproductive Endocrinology (Leung PS, Hsueh AJW and Friesen HG, eds), Karger, New York, 112-143.

  22. Forest MG, Mébarki F, Simard J, Morel Y (1994) Le déficit en 3β-hydroxystéroide déshydrogénase/Δ5-Δ4 isomérase: hétérogénéité des formes cliniques et apport de la biologie. Rev. Fr. Endocrinol. Clin., 35: 4-5.

  23. Labrie F, Simard J, Bélanger A, Luu-The V, Labrie C (1994) Molecular biology of the intracrine steroidogenic enzymes in the human prostate. In: Sex Hormones and Antihormones in Endocrine-Dependent Pathology: Basic and Clinical Aspects. New York, Elsevier, 77-92.

  24. Labrie F, Simard J, Luu-The V, Pelletier G (1994) Molecular genetics, structure-function relationships and tissue-specific expression and tissue-specific expression and regulation of the 3β-hydroxysteroid dehydrogenase/∆5-∆4 isomerase gene family. In: Function of Somatic Cells in the Testis. New York, Springer-Verlag, 126-150.

  25. Mébarki F, Morel Y, Simard J, Forest MG (1994) Les déficits en 3β-hydroxystéroïde déshydrogénase/Δ5-Δ4 isomérase: clinique et biologie moléculaire. Séminaire d'Endocrinologie Pédiatrique de l'Hôpital des Enfants Malades. 195-204.

  26. Labrie F, Bélanger A, Simard J, Luu-The V, Labrie C (1995) DHEA and peripheral androgen and estrogen formation: intracrinology. Annals of the New York Academy Sciences, 774: 16-28.

  27. Labrie F, Bélanger A, Simard J, Luu-The V, Labrie C, Cusan L, Gomez JL, Diamond P, Candas B (1996) Sources d'androgènes chez l'homme et traitement hormonal du cancer de la prostate. In: Endocrinologie Sexuelle de l'Homme (Belaisch J, Drodowsky MA, Vermeulen A, eds), Doin, 1-15.

  28. Labrie F, Cusan L, Dupont A, Gomez JL, Simard J, Luu-The V, Pelletier G, Labrie C, Bélanger A (1996) Androgen receptor antagonists. In: Reproductive Endocrinology, Surgery and Technology, (Adashi EY, Rock JA and Rosenwaks Z, eds.), New York: Raven Press, 559-584.

  29. Labrie F, Simard J, Bélanger A, Lin SX, Luu-The V, Labrie F (1996) Cancer: What are the role and sources of steroid hormones and the possible role of adipose tissue? In: Progress in obesity research. (Angel A, Anderson H, Bouchard C, Lau D, Leiter L and Mendelson R, eds), 7: 559-567.

  30. Labrie F, Simard J, Luu-The V, Pelletier G, Morel Y, Mebarki F, Sanchez R, Durocher F, Turgeon C, Labrie Y, Rhéaume E, Labrie C, Lachance Y (1996) The 3β-hydroxysteroid dehydrogenase/ isomerase gene family: lessons from type II 3β-HSD congenital deficiency. In: Proc. 9th European Testis Workshop. Signal Transduction in Testicular Cells - Basic and clinical Aspects, Springer-Verlag, 185-218.

  31. Simard J, Rhéaume E, Sanchez R, Mébarki F, Morel Y, Zerah M, New MI, Labrie F (1996) Relation between molecular defect and phenotypic manifestation of human 3β-hydroxysteroid dehydrogenase deficiency. In: Frontiers Endocrinol., Serono Symposia Series, pp. 39-68 (New, M., eds.).

  32. Durocher F, Simard J (1997) Hérédité et cancer du sein. Réseau d’échange et d’information du Québec sur le cancer du sein. 2: 10.

  33. Simard J, Labrie F (1997) Recent advances in androgen receptor research: relative potencies of pure antiandrogens and implications for prostate cancer therapy. New diagnostic and treatment modalities in prostate cancer. Projects in knowledge, 15-23.

  34. Durocher F, Simard J, Ouellette J, Richard V, Pelletier G (1998) BRCA1 gene expression in reproductive and endocrine tissues in adult cynomolgus monkey. Annals of the New York Academy Sciences, 839: 444-446.

  35. Labrie F, Simard J, Luu-The V, Labrie C, Bélanger A (1998) Adrenal androgens are responsible for 40-50% and not 5-10% of total prostatic androgens in 65-year-old men: intracrinology. In: First International Consultation on Prostate Cancer, Published on CD-ROM. Monaco.

  36. Labrie F, Bélanger A, Luu-The V, Labrie C, Simard J, Lin SX (1999) DHEA, the precursor of androgens and estrogens in peripheral target tissues in the human: intracrinology. In: The Biological Role of DHEA (Kalimi M and Regelson W, eds), (Volume II), pp. in press. Berlin, New York: Walter de Gruyter.

  37. Labrie F, Bélanger A, Luu-The V, Simard J, Lin SX, Cusan L, Labrie C (1999) Role of DHEA transformation into androgens and estrogens in peripheral intracrine tissues. DHEA Workshop. New York: Parthenon Publishing, pp.69-103.

  38. Labrie F, Bélanger A, Simard J Luu-The V, Labrie C, Lin SX, Candas B, Cusan L (1999) Impact de l’intracrinologie dans la thérapeutique et la prévention des cancers du sein et de la prostate et la ménopause. La Revue Française d’Endocrinologie Clinique Nutrition et Métabolisme. 40: 169-204.

  39. Simard J, Durocher F (1999) Hérédité et cancer du sein: Les gènes de susceptibilité BRCA1 et BRCA2. L’Actualité Médicale. 20: 4-10.

  40. Labrie C, Labrie F, Bélanger A, Simard J, Luo S, Martel C (2000) EM-652 (SCH 57068), a third generation SERM (selective estrogen receptor modulator), acting as pure antiestrogen in the mammary gland and endometrium. Current Knowledge in Reproductive Medicine. Proceedings of the 10th World Congress on Human Reproduction. Elsevier Science. Pages 381-397.

  41. Labrie F, Labrie C, Bélanger A, Simard J, Luu-The V, Candas B (2000) Mechanisms of action of estrogens and antiestrogens. The menopause at the millenium: proceedings of the 9th world congress on the ménopause, Yokohama, 14-22.

  42. Gaudet D, Laberge C, Simard J (2002) The challenge of connecting genomic knowledge to disease prevention: a canadian integrative expérience. In: Community genetics: Past and future, (Broertjes JJS, Henneman L, Beemer FA, eds.), Utrecht University, Pages 49-59.

  43. Labrie F, Bélanger A, Luu-The V, Simard J, Labrie C (2002) DHEA replacement therapy as source of androgens and estrogens at menopause. In: Gynecological Endocrinology, (Genazzani AR, Petraglia F, Artini PG, eds), London UK, Parthenon Publishing, Pages 249-258.

  44. Labrie F, Labrie C, Bélanger A, Simard J (2002) Third and fourth generation SERMs. Selective Estrogen Receptor Modulators: Research and Clinical Applications. Manni A, Verderame MF, Totowa NJ. Humana Press Inc.: 167-187.

  45. Simard J, Moisan AM, Calemard Michel L, Morel Y (2002) 17β–hydroxysteroid dehydrogenase and 5a-reductase deficiencies. In: Genetics of Steroid Biosynthesis and Function, Modern Genetics series (JI Mason, ed) – Harwood Academic Publishers. Vol 6, 297-338.

  46. Simard J, Ricketts ML, Moisan AM, Morel Y (2002) 3β–hydroxysteroid dehydrogenase Δ5-Δ4-isomerase deficiency. In: Genetics of Steroid Biosynthesis and Function, Modern Genetics series (JI Mason, ed) – Harwood Academic Publishers. Vol 6, 209-258.

  47. Godard B, Simard J, et INHERIT BRCAs (2003) Les enjeux éthiques de l’identification d’une susceptibilité génétique au cancer du sein dans un contexte de recherche clinique intégrée. In: Les pratiques de la recherche médicale visitées par la bioéthique. Eds. C Hervé, BM Knoppers, PA Molinari, Dalloz, P ages 113-136.

  48. Simard J, Dumont M, Soucy P, Labrie F, Tavtigian SV (2004) Prostate Cancer Susceptibility Genes. In: Prostate Cancer: Understanding the Pathophysiology and Re-Designing a Therapeutic Approach, (F. Labrie, M. Koutsilieries eds), Paschalidis Medical Publications, Ltd., Pages 1-38.

  49. Simard J, Joly Y, Durocher F, Knoppers BM pour INHERIT BRCAs (2005) Les enjeux éthiques du partage des résultats de recherche: L’expérience d’INHERIT BRCAS. "La recherche en génétique et en génomique: droits et responsabilités", (Philips-Nootens S, Godard B, Knoppers BM et Régnier MH, eds), Les Éditions Thémis. Pages 103-139.

  50. Labrie F, Poulin R, Simard J, Luu-The V, Labrie C, Bélanger A (2006) Androgens, DHEA and Breast Cancer. In: Androgens and Reproductive Aging. Gelfand T, ed., Oxsfordshire, UK, Taylor and Francis, Pages 113-135.

  51. Lévesque E, Bédard K, Avard D, Simard J (2009) Intégrer l’éthique dans la recherche. In : La malréglementation : Une éthique de la recherche est-elle possible et à quelles conditions? Sous la direction de Pierre Trudel et Michèle S. Jean. Les Presses de l’Université de Montréal, Pages 137-154.

  52. Morel Y, Roucher F, Plotton I, Simard J, Coll M (2014) 3ß-Hydroxysteroid Dehydrogenase Deficiency. In : Genetic Steroid Disorders. (Maria New, Oksana Lekarev, Alan Parsa, Bert O’Malley, Bert O’Malley and Gary D. Hammer eds). Academic Press. Chapter 3F, Pages 99-110.